DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3149 and rft1

DIOPT Version :9

Sequence 1:	NP_572246.1	Gene:	CG3149 / 31489	FlyBaseID:	FBgn0027564	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001072828.1	Gene:	rft1 / 780289	XenbaseID:	XB-GENE-1015143	Length:	539	Species:	Xenopus tropicalis

Alignment Length:	569	Identity:	216/569 - (37%)
Similarity:	315/569 - (55%)	Gaps:	52/569 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARNVLESSLLGAGFSIIFQILCRILTFGINAYIVRHVGREVLGIMNVRLLLLESTLLFLSREAIN 66
            ::.||..:...|.:|:|.|||.|:|||.:||:.:|:|.:|::||:||||.|..:|::||:|||..
Frog     3 SQEVLMDATKLASYSVILQILFRVLTFALNAFTLRYVSKEIIGIVNVRLTLFYTTVVFLAREAFR 67

  Fly    67 RAALSANAQQGDRCSWAQLINQMWLTVPICAVLCAPCL--YIWLNWLSAVDAIYASQYEFACYAV 129
            ||.||.:|||    ||...|:..||.||:  .:|...:  :|||..|...:......|....:|.
Frog    68 RACLSHSAQQ----SWRHTIHLTWLAVPL--GICWSFILGWIWLQILEVPEPEAIPYYNIGVWAF 126

  Fly   130 AFSCVLELMAESAVFVAQVFCFVKLKILLNTLHILVRSAIFLWIVTGDRSAAINAFAIAQLSSAV 194
            .||.|:||:||....:||...|||||::..:|.|::|.::.:.:|.......:..|::||:....
Frog   127 GFSAVVELLAEPFWVLAQAHLFVKLKVVAESLAIIIRCSVTVILVLLCPQWGLLIFSLAQVLYTS 191

  Fly   195 TIVLGQYGFFYFYLKGFKDFVTQQAKKKPVAPKAWQVSLYEHMDDFPFKQLSDFLPGVMFNPNGK 259
            .:.|....:|..:|...      :|:|||                ||.:::.:|||  .|:.:..
Frog   192 ALALCYIAYFARFLGSL------EAEKKP----------------FPLRRMREFLP--RFSSSQA 232

  Fly   260 HFNRELQTLTLSFVKQGVLKQILTEGEKYVMSVSPVLSFGEQATYDVVNNLGSMAARFIFRPIED 324
            ..:.:...|..||.||..|||||||||:|||:...|||||:|..||:||||||:.|||||.|||:
Frog   233 FLDWKQAWLAWSFFKQSFLKQILTEGERYVMTFLNVLSFGDQGVYDIVNNLGSLVARFIFLPIEE 297

  Fly   325 SSYFYFTQTLSRDIKLAKQPQERVRQASSVLNNLLLGVSSIGLIAFTFGQSYSYPVLLLYGGPDF 389
            |.|.:|.:.|.|..|:..|.:|.:..||.||.:||..|:.|||:...||.:||:..|.:||| ..
Frog   298 SFYVFFAKVLERGKKVQSQRKEEISMASEVLESLLKLVTLIGLVIIAFGYAYSHLALDIYGG-SM 361

  Fly   390 VAGGLPQSLLQWHCLAIYLLAVNGISEGYMFATNTSRDIDKYNYLMAIFSVSFLVLSYILTGIFG 454
            ::||....||:.:||.:.|||:||::|.:.||:....|:|:|||:|...|:|||.|||.:|...|
Frog   362 LSGGSGPVLLRCYCLYVLLLAINGVTECFTFASMGKEDVDRYNYVMLGLSLSFLCLSYYMTLWLG 426

  Fly   455 PVGFIFANCINMLSRILYSTYYIRHQYRPLSLDPLLGLWPGKLFGCTLFLAGIVCYWYQSSDLAT 519
            .||||.|||.||..||.:|..||...|:.....||:||.|..:..|.|.::..|..:   |::|.
Frog   427 SVGFILANCFNMGLRITHSLLYIMRYYKGSPYQPLIGLLPSPVVVCVLAVSAAVTGY---SEVAL 488

  Fly   520 -----------HLGVG-----VLAGLACLLSWALAHRDLVRLAWRYGRR 552
                       |:.||     |..|.|.|....|.|.....|..|:.|:
Frog   489 CCDKGWLLCLGHIVVGGLCLLVTLGAAVLSEKKLTHFIRSHLLSRHQRK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3149	NP_572246.1	Rft-1	8..547	CDD:282375	212/556 (38%)
rft1	NP_001072828.1	Rft-1	11..527	CDD:367971	211/549 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5343
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2310
OMA	1	1.010	-	-		QHG54409
OrthoDB	1	1.010	-	-		D338482at33208
OrthoFinder	1	1.000	-	-		FOG0004239
OrthoInspector	1	1.000	-	-		otm47563
Panther	1	1.100	-	-	LDO	PTHR13117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1092
SonicParanoid	1	1.000	-	-		X4039
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110