DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3149 and rft1

DIOPT Version :9

Sequence 1:	NP_572246.1	Gene:	CG3149 / 31489	FlyBaseID:	FBgn0027564	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_688354.3	Gene:	rft1 / 559873	ZFINID:	ZDB-GENE-110411-126	Length:	540	Species:	Danio rerio

Alignment Length:	568	Identity:	203/568 - (35%)
Similarity:	313/568 - (55%)	Gaps:	47/568 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARNVLESSLLGAGFSIIFQILCRILTFGINAYIVRHVGREVLGIMNVRLLLLESTLLFLSREAIN 66
            :.:||:|:...|.::::.|::.|:|||.:||:.:|.|.:|::|::||||:||.|||:||||||..
Zfish     3 SEDVLKSASTLASYNVLLQVMFRVLTFLLNAFTLRFVSKELIGVVNVRLMLLYSTLVFLSREAFR 67

  Fly    67 RAALSANAQQGDRCSWAQLINQMWLTVPICAV--LCAPCLYIWLNWLSAVDAIYASQYEFACYAV 129
            ||.||.   :|...:|.|:||.:|||.|:..|  :...|::.|:  |.|.|......|..|....
Zfish    68 RACLSG---EGAGRNWRQVINLLWLTFPLGCVWGVLLVCVWWWV--LQAPDPDSIPHYVPAVGLF 127

  Fly   130 AFSCVLELMAESAVFVAQVFCFVKLKILLNTLHILVRSAIFLWIVTGDRSAAINAFAIAQLSSAV 194
            ..:.:.||:||....:|....||:||::..:|.::.:..:.:.:|.......:..|:.|| ....
Zfish   128 CVAALTELLAEPLWVLAHAHMFVRLKVIAESLAMIAKCLVTVVLVVSAPQWGLFIFSAAQ-CVYT 191

  Fly   195 TIVLGQYGFFYFYLKGFKDFVTQQAKKKPVAPKAWQVSLYEHMDDFPFKQLSDFLPG-VMFNPNG 258
            ..:|..|..::.:..|     :::|:||                .||..:::|.||. |...|
Zfish   192 GFLLTCYVVYFIHFLG-----SEEAEKK----------------SFPVYRMTDLLPSKVDHEP-- 233

  Fly   259 KHFNRELQTLTLSFVKQGVLKQILTEGEKYVMSVSPVLSFGEQATYDVVNNLGSMAARFIFRPIE 323
             ..|.:|.|||.||.||..|||||||||:|||:...||:||:|..||::||||||.|||:|.|||
Zfish   234 -LLNWKLTTLTWSFFKQSFLKQILTEGERYVMTFLNVLNFGDQGVYDIINNLGSMVARFLFLPIE 297

  Fly   324 DSSYFYFTQTLSRDIKLAKQPQERVRQASSVLNNLLLGVSSIGLIAFTFGQSYSYPVLLLYGGPD 388
            :|.|.:|.:.|.|...:..|.||.|..|:.||..||..|..||||...||.:||:..|.:||| :
Zfish   298 ESFYVFFAKVLERGRDVQHQKQEEVSMAAEVLECLLKLVLLIGLIITVFGYAYSHLALDIYGG-E 361

  Fly   389 FVAGGLPQSLLQWHCLAIYLLAVNGISEGYMFATNTSRDIDKYNYLMAIFSVSFLVLSYILTGIF 453
            .::.|...:||:.:...:.|||:||::|.::||..:..::|:||.:|...|.|||:|||.||.:|
Zfish   362 LLSNGAGPALLRCYSCYVLLLAINGVTECFVFAAMSKEEVDRYNLVMLGLSASFLLLSYWLTWMF 426

  Fly   454 GPVGFIFANCINMLSRILYSTYYIRHQYRPLSLDPLLGLWPGKLFGCTLFLAGIVCYWYQSSDLA 518
            |.||||.|||.||..||.:|..|||..:......||.||.|.......|.::.::..:.:|....
Zfish   427 GGVGFILANCCNMALRITHSIVYIRQYFLQSEHRPLWGLRPHSAVLVALGVSAVITAFSESVFCC 491

  Fly   519 T--------HLGVGVLAGLACLLSWALAHRDLV-----RLAWRYGRRI 553
            .        |:.||.:..|..:::..|....||     :|..:|.:::
Zfish   492 DGGWLLRLFHVAVGAVCLLTVVITVFLTETRLVQFVKTQLLPKYNKKL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3149	NP_572246.1	Rft-1	8..547	CDD:282375	200/554 (36%)
rft1	XP_688354.3	Rft-1	14..528	CDD:282375	198/544 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590689
Domainoid	1	1.000	308	1.000	Domainoid score	I1320
eggNOG	1	0.900	-	-		E1_KOG2864
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5343
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2571
OMA	1	1.010	-	-		QHG54409
OrthoDB	1	1.010	-	-		D338482at33208
OrthoFinder	1	1.000	-	-		FOG0004239
OrthoInspector	1	1.000	-	-		oto39517
orthoMCL	1	0.900	-	-		OOG6_103267
Panther	1	1.100	-	-	LDO	PTHR13117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1092
SonicParanoid	1	1.000	-	-		X4039
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800