DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3149 and rft1

DIOPT Version :9

Sequence 1:	NP_572246.1	Gene:	CG3149 / 31489	FlyBaseID:	FBgn0027564	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_596493.1	Gene:	rft1 / 2541221	PomBaseID:	SPBC887.19	Length:	527	Species:	Schizosaccharomyces pombe

Alignment Length:	530	Identity:	139/530 - (26%)
Similarity:	220/530 - (41%)	Gaps:	128/530 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NVLESSLLGAGFSIIFQILCRILTFGINAYIVRHVGREVLGIMNVRLLLLESTLLFLSREAINRA 68
            ::|:||..|...||.||...|||||.:|...:|..........::...:|:||:||||||::..|
pombe     6 SLLQSSSKGLRSSIFFQGSSRILTFFLNQLTIRLTSPSAYAFSSIHFEILQSTILFLSRESVRLA 70

  Fly    69 ------------ALSANAQQGDRCS-WAQLI-NQMWLTVPICAVL-----------------CAP 102
                        :.|..:.:..:.| ..||| |...::|.|..|:                 ...
pombe    71 MQRIPSENAIITSTSTESNKSKKLSDQLQLIKNTSLISVYIGIVISLLVSLFYFYSLPNFPYSKT 135

  Fly   103 CLYIWLNWLSAVDAIYASQYEFACYAVAFSCVLELMAESAVFVAQVFCFVKLKILLNTLHILVRS 167
            |::|: ...|.::.:....||...:...||     ...||..:..:.|    .:|...:.:|.|
pombe   136 CIFIY-TVSSFIELLSEPYYEVLQWRQKFS-----KTASAEGLGTIIC----SLLSFAISVLGR- 189

  Fly   168 AIFLWIVTGDRSAAINAFAIAQLSSAVTIVLGQYGFFYFYLKGFKDFVTQQAKKKPVAPKAWQVS 232
                     :::.:...||:..||..|||        :|.|:.|       ||:
pombe   190 ---------NKAPSSLPFALGNLSEKVTI--------FFTLRYF-------AKQ----------- 219

  Fly   233 LYEHMDDFPFKQLSDFLPGVMFNPNGKHFNRELQTLTL--SFVKQGVLKQILTEGEKYVMS--VS 293
                    ||   |.||..|  ..|.::...:..||.:  |...|.:||.::|:|:|.:::  .|
pombe   220 --------PF---SIFLHKV--GENERYIFWDSSTLRIICSHTYQVLLKHLITKGDKIMVAWYAS 271

  Fly   294 PVLSFGEQATYDVVNNLGSMAARFIFRPIEDSSYFYFTQTLSRDIKLAKQPQERVRQASSVLNNL 358
            |    ..|..|.:.:|.||:.||.:|||:||.|:..|.|......|         :.....||.|
pombe   272 P----SAQGPYALASNYGSLLARIVFRPVEDHSHIVFAQLTHYKNK---------KDEKKALNLL 323

  Fly   359 --LLGVSSIGLIAFTFGQSYSYPVLLLYGGPDFVAGGLPQSLLQWHCLAIYLLAVNGISEG-YMF 420
              :|.:.|...:...||.:|| .::||:|.....|.....|:|.|:.:.|..:|.||:.|. |:.
pombe   324 AWILKLYSYMSLFILFGSNYS-DIVLLFGAGSKWASPDSSSILSWYAMYIPFMAANGVLEAFYVS 387

  Fly   421 ATNTSR--DIDKYNYLMAIFSVSFLVLSYILTGIF-------GPVGFIFANCINMLSRILYSTYY 476
            |.|:|:  |..|.....|:|        |.:||.|       |..|.|.||.:|:..||.::..:
pombe   388 AANSSQLYDQGKCYLASAVF--------YFITGKFLLSWFNLGSHGLILANILNLSLRICFALRF 444

  Fly   477 IRHQYRPLSL 486
            |.|.|:..||
pombe   445 ILHNYKDFSL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3149	NP_572246.1	Rft-1	8..547	CDD:282375	138/526 (26%)
rft1	NP_596493.1	MATE_rft1	10..451	CDD:240535	136/521 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	106	1.000	Domainoid score	I1671
eggNOG	1	0.900	-	-		E1_KOG2864
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5343
Inparanoid	1	1.050	110	1.000	Inparanoid score	I1579
OMA	1	1.010	-	-		QHG54409
OrthoFinder	1	1.000	-	-		FOG0004239
OrthoInspector	1	1.000	-	-		oto100517
orthoMCL	1	0.900	-	-		OOG6_103267
Panther	1	1.100	-	-	LDO	PTHR13117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1092
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860