DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PGAP1 and Pgap1

DIOPT Version :9

Sequence 1:	NP_572245.1	Gene:	PGAP1 / 31487	FlyBaseID:	FBgn0029789	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_001156786.1	Gene:	Pgap1 / 241062	MGIID:	2443342	Length:	922	Species:	Mus musculus

Alignment Length:	973	Identity:	243/973 - (24%)
Similarity:	416/973 - (42%)	Gaps:	210/973 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GLFRLHVEVEPNACRMTYMFGEPMFAKVGV--RDGDQYPNYALYYYYEGL---RQPLDPLKRRMT 81
            ||:.:....|.|.|.|:|||..|.:.|:.:  :...:||.|.||.|.||.   ...:.||    |
Mouse    24 GLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLTKRYPAYELYLYGEGSYAEEHKILPL----T 84

  Fly    82 GAPVIFVPGNAGSYKQVRSLASVALRKAMSNDAGIHLDYYTIDYDEELSALYGGYLHRQQSYLKL 146
            |.||:|:||||||||||||:.|:|||||...|...|.|:::::::|||.|||||.|.:|..::..
Mouse    85 GIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHE 149

  Fly   147 CIRTILSIYEGRTEQP-SIVLIGHSMGGKLAQSVLVDPAIGQH-INTIISISTPLDQPVLNLDTQ 209
            ||:.||.:|:|:...| |:.:|||||||.:|:::|......|. ||.:::.:||...||:.||..
Mouse   150 CIKAILKLYKGQEFAPTSVAIIGHSMGGLVARALLTLKNFKQDLINLLVTQATPHVAPVMPLDRF 214

  Fly   210 LEEFYDQTDAVLSKLRTATVPTMTTNVCDSLHQRPPSVQRMASQDSSARLDNVLLISTGGGNRDL 274
            :.|||                 |..|....|               :||..|:..:|..||.||.
Mouse   215 ITEFY-----------------MNVNNYWIL---------------NARHINLTTLSVAGGFRDY 247

  Fly   275 LVRPGLT-----SSRFNDLHAMTSAIPKVSLSCDHLSAVWCLQFMQAINRFLFSVAYVREDRSSI 334
            .||.|||     |...:.|..::||:||..:|.||||.|||.|......|..|.:  :..|...|
Mouse   248 QVRSGLTFLPKLSHYTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTIRAFFDL--IDADTKQI 310

  Fly   335 AFGTNKQRNLQTALS-TFVKPRRRQQNTVRFGAAGNWHEERRLVINKYFTNGLKGT--------- 389
               |.|.:...:.|: .|::                 |..::...|....:.|.||
Mouse   311 ---TQKPKKKLSVLNHHFIR-----------------HPAKQFEENPSIISDLTGTSMWVPVKVS 355

  Fly   390 -------------FFDLIGLQRQERYRKAAIEALNVDDEDWLFGCSAEDNNKTGQLYCEKATSLM 441
                         :|.......::.|..|..::..:|...|:|||.    |.|..  |.:...|.
Mouse   356 RWSYVAYNESDKIYFAFPLANHRKIYTHAYCQSTMLDTNSWIFGCI----NSTSM--CRQGVDLS 414

  Fly   442 HLVQWLPNEDREPRSIALLDLHNLRKTYVHWTHLLVRLPPSAKRIGYNLDIYDPKERVTDIKMPR 506
            ...:.||       :|..|.|.  .:.|...:|::|.: ||.....:.:|....|:....:::|.
Mouse   415 WKAELLP-------TIKSLTLR--LQDYPSLSHIVVYV-PSVHGSKFVVDCEFFKKEARSMQLPV 469

  Fly   507 WYTMA-KLPLINETLQ-GTLHHRVRISEMVDPYQSIRVIVEPLQCINPEYRVTA--RICVPWAAG 567
            .:..: .|.....||. ..|::.:.:......||:.:|.|.. :|...:..:|:  ::.:||:
Mouse   470 THLFSFGLSSRKVTLNTNGLYYNIELLNFGQIYQAFKVNVVS-KCTGSKEEITSIYKLHIPWS-- 531

  Fly   568 FERFQTL----KSFDQKPQLYVNVPTLVPRHYNTTLNPVTLELYLDPTCRYRISYEYSYSSALSR 628
            :|...|:    .|.|...:|:|..|       ....:...|::|....|:|.::.:.|:...|.:
Mouse   532 YEDSLTIAQVPSSTDISLKLHVAQP-------ENDSHVALLKMYTSSDCQYEVTIKTSFPQILGQ 589

  Fly   629 LVLEFYGWLPAHLVCVLLIVLRKQVETFYDVG--------TFRSLRPY------------VGYLQ 673
            :|....|.|||::|..:|:....|:.:....|        ..:..:||            :||..
Mouse   590 VVRFHGGALPAYVVSSILLAYGGQLYSLLSTGYCLEYSTILDKEAKPYKVDPFVIMIKFLLGYKW 654

  Fly   674 YTSLYIVTACRLLKKLIISSR--VFPEPEPLDYSINVSIVIH----CAAIALSLLATLGTWLALT 732
            :..|:.......|..::::|:  .||         .||:::.    |.|....||::....|..:
Mouse   655 FKELWDAVLLPELDAIVLTSQSMCFP---------LVSLILFLFGTCTAYWSGLLSSTSVQLLSS 710

  Fly   733 LYGNAFYRLALRITRLSQATSNVMISIMTHLPITYGILTIATAMGTCSGVGLLLAFVFYFLMLSN 797
            |:      |||:  |.::...::.: :...||: ..::.:..:..||..:.:||::::|..
Mouse   711 LW------LALK--RPAELPKDIKV-MSPDLPV-LTVVFLIVSWTTCGALAILLSYLYYVF---- 761

  Fly   798 AYKDYLEDFLWQKAANLVRGKPSAVTEQEDATEEQNEEQNALKQNDEQKQQQQEEEEPEACVGL- 861
                        |..:|    .:::|     |.:.|:..|.......:|:....::.....:.|
Mouse   762 ------------KVVHL----QASLT-----TFKNNQPVNPKHSRRSEKKSNHHKDSAVQSLRLC 805

  Fly   862 -----QNFSFHVTLLLMLFVQLLLNAPSSLAWLRSRRHGINL-PDPS------LYPSIVVLAS 912
                 .:...|.|::.:|...:||:.||.:.||::.|:...| |||.      |.|:|.:|.:
Mouse   806 ANDAEDSLRMHSTVINLLTWVVLLSMPSLIYWLKNLRYYFKLSPDPCKPLAFLLIPAIAILGN 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGAP1	NP_572245.1	PGAP1	79..324	CDD:285110	98/251 (39%)
Pgap1	NP_001156786.1	PGAP1	83..302	CDD:285110	99/254 (39%)
Pgap1	NP_001156786.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	776..798		3/21 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830679
Domainoid	1	1.000	155	1.000	Domainoid score	I4230
eggNOG	1	0.900	-	-		E1_KOG3724
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41605
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3575
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45558
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004158
OrthoInspector	1	1.000	-	-		oto94116
orthoMCL	1	0.900	-	-		OOG6_106919
Panther	1	1.100	-	-	LDO	PTHR15495
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R151
SonicParanoid	1	1.000	-	-		X2907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790