DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PGAP1 and nhr-49

DIOPT Version :9

Sequence 1:	NP_572245.1	Gene:	PGAP1 / 31487	FlyBaseID:	FBgn0029789	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_001367039.1	Gene:	nhr-49 / 172839	WormBaseID:	WBGene00003639	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	293	Identity:	65/293 - (22%)
Similarity:	108/293 - (36%)	Gaps:	91/293 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 PRRRQQNTVRFGAAGNWHEERRLVINKYFTNGLKGTFFDLIGLQRQE---RYRKAAIEA-----L 410
            |.....|:...|:.|...|..|.|..   ::.:.....::.....||   |||::.|.|     .
Worm   132 PGYENGNSNGVGSNGMGQENMRTVPQ---SSSVIDALMEMEARVNQEMCNRYRRSQIFANGSGGS 193

  Fly   411 NVDDEDWLFG--------------CSAE-DNNKTGQLYCEKATSLMHLVQW---------LPNED 451
            |.:|.|...|              |:.| |.|:..:      |:|:.:|:|         |..||
Worm   194 NGNDTDIQQGSDSGASAFAPPNRPCTTEVDLNEISR------TTLLLMVEWAKTINPFMDLSMED 252

  Fly   452 REPRSIALLDLHNLRKTYVHWTHLLVRLP----PSAKRIGYNLDIYDPKERVTDIKMPRWYTMAK 512
            :    |.||      |.|.. .||:: :|    |...|:....:.|..::..||:.     ..|.
Worm   253 K----IILL------KNYAP-QHLIL-MPAFRSPDTTRVCLFNNTYMTRDNNTDLN-----GFAA 300

  Fly   513 LPLINETLQGTLHHRVRISEMVDPYQSIR------VIVEPLQCINPEYR---VTARICVPWAAGF 568
            ....|.|      .|| :.|:|.|.:.::      |.::.|..::||.:   .:::|.:..|
Worm   301 FKTSNIT------PRV-LDEIVWPMRQLQMREQEFVCLKALAFLHPEAKGLSNSSQIMIRDA--- 355

  Fly   569 ERFQTLKSF---------DQKPQLYVNVPTLVP 592
             |.:.||:.         |..|..|.|:..|.|
Worm   356 -RNRVLKALYAFILDQMPDDAPTRYGNILLLAP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGAP1	NP_572245.1	PGAP1	79..324	CDD:285110
nhr-49	NP_001367039.1	NR_DBD_HNF4A	35..110	CDD:143518
nhr-49	NP_001367039.1	HOLI	228..382	CDD:214658	40/187 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S163
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950