Protein Alignment CG4119 and RBM25

DIOPT Version :9

• Sequence 1: NP_001284899.1
• Gene: CG4119 / 31481
• FlyBaseID: FBgn0028474
• Length: 998
• Species: Drosophila melanogaster
• Sequence 2: NP_067062.1
• Gene: RBM25 / 58517
• HGNCID: 23244
• Length: 843
• Species: Homo sapiens
• Alignment Length: 1073
• Identity: 355/1073 - (33%)
• Similarity: 500/1073 - (46%)
• Gaps: 310/1073 - (28%)

  Fly     1 MSYPPRAPMPPF----MNTAIPPPHIM---------QNMAKPPRSFRNSATISSQPTVYQ----- 47
            ||:||....||.    :...||||...         ..|...|.|....|.....|||..
Human     1 MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHL 65

  Fly    48 --RPPEPQPQFR------GPIITVFVGNISERVPEALLKRILNACGVVINWKRV-------STFG 97
              |...|..:.:      ||..|||||||||:..:.|::::|..||:|::||||       ..||
Human    66 GARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFG 130

  Fly    98 FCEFDGPIAAMRAVRLLSEMEIDGKKLVAKVDAKNKVLIEDYK-EQECKNG---------DRSNP 152
            |||:..|.:.:||:|||.:::|..|||:.|||||.|..::::| :::..||         |....
Human   131 FCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEA 195

  Fly   153 VDEKTE--DEFAIAQMHEFLEEHKHEFEGFDSSSRADLYGSANRNKKTRREEDIKMK-------- 207
            :||:|:  |:.....:...:.|:..|...  .|..:|   |..|.||..::|||..:
Human   196 LDEETKRRDQMIKGAIEVLIREYSSELNA--PSQESD---SHPRKKKKEKKEDIFRRFPVAPLIP 255

  Fly   208 ---VLSEN----TLEEEKRNLISSEIGKFR---MRAEEDEHRKELEKEK-EKEKLAASKEKERKK 261
               :..|:    .:||:||:|||.||.|||   .:.||::.:||.|::: |||:    :|:||::
Human   256 YPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKER----RERERER 316

  Fly   262 QREMERMSSTSKSGSSSTAAASSSSATATSSTPAADGADMSDKTDKESVAVVIKETVKESKESAS 326
            :||.||                                               :|..:|.:....
Human   317 ERERER-----------------------------------------------RERERERERERE 334

  Fly   327 STGRKESSSAAIEITQKERRSD-----SKETRRRRSKSRSKDRERERERELRELRDKERERERDR 386
            ....||        .::||..|     :||..|.|.:.|.:||:|||..:..:.|.:.||:.|||
Human   335 REKEKE--------RERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDR 391

  Fly   387 ERERERERNEMRERERNEMREREREREREREREEKLLKPVRDTWREKEM-EDELRDRKKAEKKAR 450
            ||||||||...|||||...||||||||||||||.:     :|..|::|. |::..:|:|.|:|.|
Human   392 ERERERERERERERERERERERERERERERERERE-----KDKKRDREEDEEDAYERRKLERKLR 451

  Fly   451 EKEIAYQTRLTDWEVREKRKAKENEKYRLKELLRQEERETDAKRLKEFVEDYDDERDDSLYYRGR 515
            |||.|||.||.:||:||::|.:|.||...:|..|:.|...:|||||||:|||||:|||..||||.
Human   452 EKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516

  Fly   516 ELQQRLAERVREADADSKDREKEAEELAELKSKFFSGEYENPSLEFEKARLEIEKLYEPRILINV 580
            .||:||.:|.:|.:||.:||::|.|||.|::.:..:..:.:|..|.::...|.|:..:|:|
Human   517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQI---- 577

  Fly   581 NQEPPAAATSSVHQRKQAASAPGEDDEGQKQRQKSQQLDSYDPDMAGTNDDDSISNDDRASMADT 645
            .|||.:.......|.|:.     :.:|..::.::.:|.....|.:.            ..|.|.:
Human   578 KQEPESEEEEEEKQEKEE-----KREEPMEEEEEPEQKPCLKPTLR------------PISSAPS 625

  Fly   646 ASNASGVYAKNNNNDQSLSNSLSRHNSESRDSLAQIHTPTQSAILNDQESGHDAILPSATPPMTM 710
            .|:|||....|...|:|....:..|.:.......:.|.|...
Human   626 VSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIG----------------------- 667

  Fly   711 PLISLTLG--------NNLKKKKIEATGVFVNDDDNDENINPKKRKLVPLDYDDNISNTTPSNHA 767
              :||.||        |::|:||:....||...:|.|.:..|:|||||||||.::..|.|
Human   668 --LSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNAT----- 725

  Fly   768 ASSGSGAANNSSSSNNNNSSSADRQSSAVSAATAAAAAVSQKIAQAFGGGSSGSGSGSGSGSNAS 832
                .|..|.
Human   726 ----KGTVNT------------------------------------------------------- 731

  Fly   833 GGKNNGGGSSSSSNNKHNSNSKHGKNEAAASAGSSADAAAANIKKDENGAKVYDEKRRHIKSIID 897
                                                                 :|||:||||:|:
Human   732 -----------------------------------------------------EEKRKHIKSLIE 743

  Fly   898 RIPTQKEELFNYKLDRNEIDSGLMERKIRPWINKKIIEYIGEPEPTLVDFICSKVLAGSPPQSIL 962
            :|||.|.|||.|.||.:.:||.||||:|||||||||||||||.|.|||||:||||:|.|.|||||
Human   744 KIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSIL 808

  Fly   963 DDVQMVLDEEAEVFVVKMWRLLIYELDAKKSGL 995
            |||.||||||||||:||||||||||.:|||.||
Human   809 DDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGL 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4119	NP_001284899.1	RRM_RBM25	62..136	CDD:240892	39/80 (49%)
		PWI	917..988	CDD:214609	60/70 (86%)
RBM25	NP_067062.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		10/28 (36%)
		RRM_RBM25	87..169	CDD:409880	39/81 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..202		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..243		7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..442		74/225 (33%)
		Necessary for nuclear speckle localization	285..644		151/443 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..688		61/235 (26%)
		PWI	763..836	CDD:214609	61/72 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146092
Domainoid	1	1.000	287	1.000	Domainoid score	I1587
eggNOG	1	0.900	-	-		E1_KOG2253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2208
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59586
OrthoDB	1	1.010	-	-		D378934at33208
OrthoFinder	1	1.000	-	-		FOG0003333
OrthoInspector	1	1.000	-	-		oto88619
orthoMCL	1	0.900	-	-		OOG6_103133
Panther	1	1.100	-	-	LDO	PTHR18806
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1872
SonicParanoid	1	1.000	-	-		X3224
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.890