DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4119 and Rbm25

DIOPT Version :9

Sequence 1:	NP_001284899.1	Gene:	CG4119 / 31481	FlyBaseID:	FBgn0028474	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	XP_038968572.1	Gene:	Rbm25 / 366693	RGDID:	1308755	Length:	855	Species:	Rattus norvegicus

Alignment Length:	1067	Identity:	354/1067 - (33%)
Similarity:	498/1067 - (46%)	Gaps:	305/1067 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSYPPRAPMPPF----MNTAIPPPHIM---------QNMAKPPRSFRNSATISSQPTVYQ----- 47
            ||:||....||.    :...||||...         ..|...|.|....|.....|||..
  Rat    20 MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHL 84

  Fly    48 --RPPEPQPQFR------GPIITVFVGNISERVPEALLKRILNACGVVINWKRV-------STFG 97
              |...|..:.:      ||..|||||||||:..:.|::::|..||:|::||||       ..||
  Rat    85 GARKDHPGLKLKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFG 149

  Fly    98 FCEFDGPIAAMRAVRLLSEMEIDGKKLVAKVDAKNKVLIEDYKEQECKNG---------DRSNPV 153
            |||:..|.:.:||:|||.:::|..|||:.|||||.|..::::|.::..||         |....:
  Rat   150 FCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKANGNARPETVTNDDEEAL 214

  Fly   154 DEKTE--DEFAIAQMHEFLEEHKHEFEGFDSSSRADLYGSANRNKKTRREEDIKMK--------- 207
            ||:|:  |:.....:...:.|:..|...  .|..:|   |..|.||..::|||..:
  Rat   215 DEETKRRDQMIKGAIEVLIREYSSELNA--PSQESD---SHPRKKKKEKKEDIFRRFPVAPLIPY 274

  Fly   208 --VLSEN----TLEEEKRNLISSEIGKFR---MRAEEDEHRKELEKEK-EKEKLAASKEKERKKQ 262
              :..|:    .:||:||:|||.||.|||   .:.||::.:||.|::: |||:    :|:||:::
  Rat   275 PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKER----RERERERE 335

  Fly   263 REMERMSSTSKSGSSSTAAASSSSATATSSTPAADGADMSDKTDKESVAVVIKETVKESKESASS 327
            ||.||                                               :|..:|.:.....
  Rat   336 RERER-----------------------------------------------RERERERERERER 353

  Fly   328 TGRKESSSAAIEITQKERRSDSKETRRR-RSKSRSKDRERERERELRELRDKERERERDRERERE 391
            ...||..      .::||..|...|:.| |.:.|.:||:|||..:..:.|.:.||:.||||||||
  Rat   354 EKEKERE------RERERDRDRDRTKERDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 412

  Fly   392 RERNEMRERERNEMREREREREREREREEKLLKPVRDTWREKEMEDELRDRKKAEKKAREKEIAY 456
            |||...|||||...||||||||||||:::|     ||  ||::.||.. :|:|.|:|.||||.||
  Rat   413 REREREREREREREREREREREREREKDKK-----RD--REEDEEDAY-ERRKLERKLREKEAAY 469

  Fly   457 QTRLTDWEVREKRKAKENEKYRLKELLRQEERETDAKRLKEFVEDYDDERDDSLYYRGRELQQRL 521
            |.||.:||:||::|.:|.||...:|..|:.|...:|||||||:|||||:|||..||||..||:||
  Rat   470 QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRL 534

  Fly   522 AERVREADADSKDREKEAEELAELKSKFFSGEYENPSLEFEKARLEIEKLYEPRILINVNQEPPA 586
            .:|.:|.:||.:||::|.|||.|::.:..:..:.:|..|.::...|.|:..:|:|    .|||.:
  Rat   535 RDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQI----KQEPES 595

  Fly   587 AATSSVHQRKQAASAPGEDDEGQKQRQKSQQLDSYDPDMAGTNDDDSISNDDRASMADTASNASG 651
            .......|.|:.     :.:|..::.::.:|.....|.:.            ..|.|.:.|:|||
  Rat   596 EEEEEEKQEKEE-----KREEPVEEEEEPEQKPCLKPTLR------------PISSAPSVSSASG 643

  Fly   652 VYAKNNNNDQSLSNSLSRHNSESRDSLAQIHTPTQSAILNDQESGHDAILPSATPPMTMPLISLT 716
            ....|...|:|....:..|.:.......:.|.|...                         :||.
  Rat   644 NATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIG-------------------------LSLK 683

  Fly   717 LG--------NNLKKKKIEATGVFVNDDDNDENINPKKRKLVPLDYDDNISNTTPSNHAASSGSG 773
            ||        |::|:||:....||...:|.|.:..|:|||||||||.::..|         :..|
  Rat   684 LGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKN---------AAKG 739

  Fly   774 AANNSSSSNNNNSSSADRQSSAVSAATAAAAAVSQKIAQAFGGGSSGSGSGSGSGSNASGGKNNG 838
            ..|.
  Rat   740 TVNT------------------------------------------------------------- 743

  Fly   839 GGSSSSSNNKHNSNSKHGKNEAAASAGSSADAAAANIKKDENGAKVYDEKRRHIKSIIDRIPTQK 903
                                                           :|||:||||:|::|||.|
  Rat   744 -----------------------------------------------EEKRKHIKSLIEKIPTAK 761

  Fly   904 EELFNYKLDRNEIDSGLMERKIRPWINKKIIEYIGEPEPTLVDFICSKVLAGSPPQSILDDVQMV 968
            .|||.|.||.:.:||.||||:|||||||||||||||.|.|||||:||||:|.|.||||||||.||
  Rat   762 PELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMV 826

  Fly   969 LDEEAEVFVVKMWRLLIYELDAKKSGL 995
            ||||||||:||||||||||.:|||.||
  Rat   827 LDEEAEVFIVKMWRLLIYETEAKKIGL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4119	NP_001284899.1	RRM_RBM25	62..136	CDD:240892	39/80 (49%)
CG4119	NP_001284899.1	PWI	917..988	CDD:214609	60/70 (86%)
Rbm25	XP_038968572.1	RRM_RBM25	106..188	CDD:409880	39/81 (48%)
Rbm25	XP_038968572.1	PWI	775..848	CDD:214609	61/72 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5873
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003333
OrthoInspector	1	1.000	-	-		otm44600
orthoMCL	1	0.900	-	-		OOG6_103133
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810