Protein Alignment Sirt4 and SIR2

DIOPT Version :9

• Sequence 1: NP_572241.2
• Gene: Sirt4 / 31480
• FlyBaseID: FBgn0029783
• Length: 312
• Species: Drosophila melanogaster
• Sequence 2: NP_010242.1
• Gene: SIR2 / 851520
• SGDID: S000002200
• Length: 562
• Species: Saccharomyces cerevisiae
• Alignment Length: 328
• Identity: 84/328 - (25%)
• Similarity: 129/328 - (39%)
• Gaps: 83/328 - (25%)

  Fly    37 RLEDF---------LLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHME------- 85
            ||.:|         |.:...:|||||||:||..||||:|| ..|.|::..|..:...:
Yeast   237 RLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRS-SEGFYSKIKHLGLDDPQDVFNYNI 300

  Fly    86 FVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNV 148
            |:...:|  .|...|.| .|......|  .|..:...:.:.::....|||:|.|.:.||  :..:
Yeast   301 FMHDPSV--FYNIANMV-LPPEKIYSP--LHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL 360

  Fly   149 VEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPL---------EYI- 203
            |:.|||.....|::|.:.:......:.:.:|                 |:||         ||.
Yeast   361 VQCHGSFATATCVTCHWNLPGERIFNKIRNL-----------------ELPLCPYCYKKRREYFP 408

  Fly   204 ENF---------------RIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSS 253
            |.:               |.|......|.|||:|.|||:::|......|...:...|.|:.:|:|
Yeast   409 EGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTS 473

  Fly   254 L----------LVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADI--KISAKCGDVIP--KLFD 304
            |          :|.|....||..:|   ||.......:...:..||  .::.|||..||  |..|
Yeast   474 LKVAPVSEIVNMVPSHVPQVLINRD---PVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWND 535

  Fly   305 FRN 307
            .:|
Yeast   536 LKN 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	78/315 (25%)
SIR2	NP_010242.1	DUF592	104..261	CDD:368003	6/23 (26%)
		SIRT1	255..517	CDD:238699	71/287 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810