DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt4 and sirt4

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001005988.1	Gene:	sirt4 / 791628	ZFINID:	ZDB-GENE-041010-65	Length:	310	Species:	Danio rerio

Alignment Length:	282	Identity:	142/282 - (50%)
Similarity:	192/282 - (68%)	Gaps:	0/282 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHME 85
            :::||.........:::|:.|:.....:.|::|||:|||||||||||||||||||:|.:|:||.|
Zfish    26 RQFVPASGSFDSSALEQLQAFISQASRLFVISGAGLSTESGIPDYRSEGVGLYARTNRRPMQHSE 90

  Fly    86 FVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVE 150
            ||:|...|:||||||:||||:||:.|||:.|.||..:|.:.::..:||||||.||.|||.:.:.|
Zfish    91 FVRSEKSRQRYWARNYVGWPQFSSHQPNSAHLALRDWEEKGKLHWLVTQNVDALHLKAGQQRLTE 155

  Fly   151 VHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCG 215
            :|||.:.|.||.|.....|.|.|....:|||.::.....:.|||||.:..|.:.|||:|.|..||
Zfish   156 LHGSTHRVVCLDCGELTPRAELQKRFTALNPGWEATACAVAPDGDVFLEEEQVLNFRVPACNACG 220

  Fly   216 GDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGE 280
            |.||||:.||||.|.|..|..:...:..||.:||.||||.||||||.:|...:.|||:.|||||.
Zfish   221 GVLKPEVTFFGDVVNRNTVHFVHNKLAESDAVLVAGSSLQVFSGYRFLLAASERKLPIAIVNIGA 285

  Fly   281 TRADHLADIKISAKCGDVIPKL 302
            ||||||.||::||:||:|:|.:
Zfish   286 TRADHLTDIRVSARCGEVLPAI 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	138/260 (53%)
sirt4	NP_001005988.1	SIRT4	43..304	CDD:238700	138/260 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586313
Domainoid	1	1.000	224	1.000	Domainoid score	I2483
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8164
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2729
OMA	1	1.010	-	-		QHG56570
OrthoDB	1	1.010	-	-		D1407693at2759
OrthoFinder	1	1.000	-	-		FOG0005863
OrthoInspector	1	1.000	-	-		oto39744
orthoMCL	1	0.900	-	-		OOG6_103918
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2794
SonicParanoid	1	1.000	-	-		X4258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800