Protein Alignment Sirt4 and Sirt1

DIOPT Version :9

• Sequence 1: NP_572241.2
• Gene: Sirt4 / 31480
• FlyBaseID: FBgn0029783
• Length: 312
• Species: Drosophila melanogaster
• Sequence 2: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 77/279 - (27%)
• Similarity: 111/279 - (39%)
• Gaps: 80/279 - (28%)

  Fly    22 EYVPH--HKPVVEDDIKRLEDF-----LLSK-PNVLVLTGAGISTESGIPDYRSEGVGLYARSNH 78
            :|:.|  ::|...:.:..:..|     |:.| ..::||||||:|...||||:||.. |:|||..|
  Fly   190 DYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTN-GIYARLAH 253

  Fly    79 ------KPVQHMEFVKSSAVRKRYWARNFVGWPKFSAT------QPNATHHALARFEREERVQAV 131
                  .|....:.        .|:.|:...:.||:..      ||:..|..:...|.:.::...
  Fly   254 DFPDLPDPQAMFDI--------NYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRN 310

  Fly   132 VTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDV 196
            .|||:|.|...||.:.|:|.|||.....|..|.                  ||...|.:|.|
  Fly   311 YTQNIDTLERVAGIQRVIECHGSFSTASCTKCR------------------FKCNADALRAD--- 354

  Fly   197 EIPLEYIENFRIPECTQC------------------------GGDLKPEIVFFGDSVPRPRVDQI 237
                  |...|||.|.||                        .|.:||:|||||:.:|......:
  Fly   355 ------IFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVM 413

  Fly   238 AGMVYNSDGLLVLGSSLLV 256
            |......|.|:|:||||.|
  Fly   414 ATDKDVCDLLIVIGSSLKV 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	74/261 (28%)
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	4/25 (16%)
		SIRT1	222..476	CDD:238699	71/247 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438949
Domainoid	1	1.000	54	1.000	Domainoid score	I647
eggNOG	1	0.900	-	-		E1_COG0846
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51312
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840