Protein Alignment Sirt4 and sirt2

DIOPT Version :10

• Sequence 1: NP_572241.2
• Gene: Sirt4 / 31480
• FlyBaseID: FBgn0029783
• Length: 312
• Species: Drosophila melanogaster
• Sequence 2: NP_955890.1
• Gene: sirt2 / 322309
• ZFINID: ZDB-GENE-030131-1028
• Length: 379
• Species: Danio rerio
• Alignment Length: 276
• Identity: 69/276 - (25%)
• Similarity: 123/276 - (44%)
• Gaps: 58/276 - (21%)

  Fly    25 PHHKPVVEDDIKRLEDFLLSK--PNVLVLTGAGISTESGIPDYRSEGVGLYARSNH------KPV 81
            |..|.:.|..:..:..::||.  .|::.:.||||||.:||||:||.|.||||....      :.:
Zfish    52 PGDKVLDELTLDSVARYILSGKCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLPYPEAI 116

  Fly    82 QHMEFVKSS-----AVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHT 141
            ..:::.|..     |:.:..:...|         :|...|:.:...:.:..::...:||:|.|..
Zfish   117 FQIDYFKKHPEPFFALARELYPGQF---------KPTVYHYFIKMLKDKGLLRRCYSQNIDTLER 172

  Fly   142 KAG--SRNVVEVHGSGYVVKCLS--C--EYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPL 200
            .||  ..:::|.||:.:...|:|  |  ||.:|..:        |..|.:
Zfish   173 VAGLEGEDLIEAHGTFHTSHCVSFLCRKEYSMDWMK--------NQIFSE--------------- 214

  Fly   201 EYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQ 265
                  .||:|..||..:||:|||||:|:|......:.......|.|:::|:||.|.....:|.:
Zfish   215 ------EIPKCDSCGSLVKPDIVFFGESLPSRFFTSMKADFPQCDLLIIMGTSLQVQPFASLVSR 273

  Fly   266 TKDLKLPVGIVNIGET 281
            ..: :.|..::|:.:|
Zfish   274 VSN-RCPRLLINMEKT 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	66/263 (25%)
sirt2	NP_955890.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		SIRT1	75..328	CDD:238699	64/253 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..379