DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt4 and Sirt4

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001100617.2	Gene:	Sirt4 / 304539	RGDID:	1310413	Length:	319	Species:	Rattus norvegicus

Alignment Length:	303	Identity:	145/303 - (47%)
Similarity:	208/303 - (68%)	Gaps:	9/303 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LRFRST---------SLRSSTARQEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGISTESGI 62
            |.||.|         .|||..:...:||...|:..:.||.|:.|:.....:||:|||||||||||
  Rat    12 LIFRPTRGRWITQMSQLRSHGSTGLFVPPSPPLDHEKIKELQRFISLSKKLLVMTGAGISTESGI 76

  Fly    63 PDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREER 127
            ||||||.||||||::.:|:||::|::|:.||:|||||||||||:||:.|||..|.||:.:|:..:
  Rat    77 PDYRSEKVGLYARTDRRPIQHIDFIRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWEKLGK 141

  Fly   128 VQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRP 192
            :..:||||||.||:|||::.:.|:||..:.|.||||..:..|...|....:|||::......:.|
  Rat   142 LHWLVTQNVDALHSKAGNQRLTELHGCMHRVLCLSCGEQTARRVLQDRFQALNPSWSAEAQGVAP 206

  Fly   193 DGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVF 257
            ||||.:..|.:.:||:|.|.:|||.|||::|||||:|...:||.:...|..:|.|||:||||.|:
  Rat   207 DGDVFLTEEQVRSFRVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHQRVKEADSLLVVGSSLQVY 271

  Fly   258 SGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIP 300
            ||||.:|..::.|||:.|:|||.||:|.||.:|:.::||:::|
  Rat   272 SGYRFILTAREKKLPIAILNIGPTRSDDLACLKLDSRCGELLP 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	132/260 (51%)
Sirt4	NP_001100617.2	SIRT4	52..313	CDD:238700	131/254 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345225
Domainoid	1	1.000	226	1.000	Domainoid score	I2428
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8164
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2652
OMA	1	1.010	-	-		QHG56570
OrthoDB	1	1.010	-	-		D1407693at2759
OrthoFinder	1	1.000	-	-		FOG0005863
OrthoInspector	1	1.000	-	-		oto95460
orthoMCL	1	0.900	-	-		OOG6_103918
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770