DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt4 and SIRT1

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_036370.2	Gene:	SIRT1 / 23411	HGNCID:	14929	Length:	747	Species:	Homo sapiens

Alignment Length:	296	Identity:	84/296 - (28%)
Similarity:	133/296 - (44%)	Gaps:	73/296 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYAR--------SNHKPVQHMEFV 87
            :||.:|.|::.    ..::||||||:|...||||:||.. |:|||        .:.:.:..:|:.
Human   243 IEDAVKLLQEC----KKIIVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPDPQAMFDIEYF 302

  Fly    88 KSSAVRKRYWARNFVGWPKFSAT------QPNATHHALARFEREERVQAVVTQNVDRLHTKAGSR 146
            :..       .|.|.   ||:..      ||:..|..:|..::|.::....|||:|.|...||.:
Human   303 RKD-------PRPFF---KFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQ 357

  Fly   147 NVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPEC 211
            .:::.|||.....||.|:|::|                  .:.:|.|         |.|..:|.|
Human   358 RIIQCHGSFATASCLICKYKVD------------------CEAVRGD---------IFNQVVPRC 395

  Fly   212 TQCGGD-----LKPEIVFFGDSVPRPRVDQI-AGMVYNSDG---LLVLGSSLLVFSGYRVVLQTK 267
            .:|..|     :||||||||:::|    :|. ..|.|:.|.   |:|:||||.|   ..|.|...
Human   396 PRCPADEPLAIMKPEIVFFGENLP----EQFHRAMKYDKDEVDLLIVIGSSLKV---RPVALIPS 453

  Fly   268 DLKLPVGIVNIGETRADHL-ADIKISAKCGDVIPKL 302
            .:...|..:.|......|| .|:::...|..:|.:|
Human   454 SIPHEVPQILINREPLPHLHFDVELLGDCDVIINEL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	79/284 (28%)
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135
		Interaction with H1-4. /evidence=ECO:0000269\|PubMed:15469825	2..268		11/28 (39%)
		Interaction with CLOCK. /evidence=ECO:0000250\|UniProtKB:Q923E4	2..139
		Nuclear localization signal. /evidence=ECO:0000250	32..39
		Nuclear export signal. /evidence=ECO:0000250	138..145
		Interaction with CCAR2	143..541		84/296 (28%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230
		SIRT1	254..489	CDD:238699	79/279 (28%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269\|PubMed:25406032	256..259		0/2 (0%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..549
		Phosphorylated at one of three serine residues	538..540
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810