Protein Alignment Sirt4 and SIRT3

DIOPT Version :10

• Sequence 1: NP_572241.2
• Gene: Sirt4 / 31480
• FlyBaseID: FBgn0029783
• Length: 312
• Species: Drosophila melanogaster
• Sequence 2: NP_001357239.1
• Gene: SIRT3 / 23410
• HGNCID: 14931
• Length: 417
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 74/275 - (26%)
• Similarity: 116/275 - (42%)
• Gaps: 70/275 - (25%)

  Fly    48 VLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHMEFV-----------KSSAVRKRYWARNF 101
            |:|:.||||||.|||||:||.|.|||:......:.:.|.:           ....:.|..:..|:
Human   140 VVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNY 204

  Fly   102 VGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVHGSGYVVKCLSCE 164
                     :||.||:.|.....:..:..:.|||:|.|...:|  :..:||.||:.....|..|:
Human   205 ---------KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQ 260

  Fly   165 YRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSV 229
                                      ||....:|..:.:.: |:|.|..|.|.:||:|||||:.:
Human   261 --------------------------RPFPGEDIRADVMAD-RVPRCPVCTGVVKPDIVFFGEPL 298

  Fly   230 PRPRVDQIAGMVYNSDGLLVLGSSL----------LVFSGYRVVLQTKDLKLPVGIVNIGETRAD 284
            |:..:..:..... :|.||:||:||          .|.|....:|..:||..|:         |.
Human   299 PQRFLLHVVDFPM-ADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPL---------AW 353

  Fly   285 HLADIKISAKCGDVI 299
            |.....: |:.|||:
Human   354 HPRSRDV-AQLGDVV 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	73/273 (27%)
SIRT3	NP_001357239.1	SIRT1	138..373	CDD:238699	74/275 (27%)