Protein Alignment Sirt4 and SIRT4

DIOPT Version :10

• Sequence 1: NP_572241.2
• Gene: Sirt4 / 31480
• FlyBaseID: FBgn0029783
• Length: 312
• Species: Drosophila melanogaster
• Sequence 2: NP_036372.1
• Gene: SIRT4 / 23409
• HGNCID: 14932
• Length: 314
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 146/309 - (47%)
• Similarity: 205/309 - (66%)
• Gaps: 9/309 - (2%)

  Fly     1 MRVGQLLRFRSTSLR---------SSTARQEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGI 56
            |::...|.|||...|         |..:...:||...|:..:.:|.|:.|:.....:||:|||||
Human     1 MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGI 65

  Fly    57 STESGIPDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALAR 121
            ||||||||||||.||||||::.:|:||.:||:|:.:|:|||||||||||:||:.|||..|.||:.
Human    66 STESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALST 130

  Fly   122 FEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDA 186
            :|:..::..:||||||.||||||||.:.|:||....|.||.|..:..|...|.....|||.:...
Human   131 WEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAE 195

  Fly   187 PDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLG 251
            ...:.|||||.:..|.:.:|::|.|.||||.|||::|||||:|...:||.:...|..:|.|||:|
Human   196 AHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVG 260

  Fly   252 SSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIP 300
            |||.|:||||.:|...:.|||:.|:|||.||:|.||.:|::::||:::|
Human   261 SSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLP 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	134/260 (52%)
SIRT4	NP_036372.1	SIRT4	47..308	CDD:238700	134/260 (52%)
		sirtuin core domain	55..314		133/255 (52%)