DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt4 and SIRT2

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_036369.2	Gene:	SIRT2 / 22933	HGNCID:	10886	Length:	389	Species:	Homo sapiens

Alignment Length:	248	Identity:	68/248 - (27%)
Similarity:	105/248 - (42%)	Gaps:	58/248 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VLVLTGAGISTESGIPDYRSEGVGLY--ARSNHKP----VQHMEFVKSS-----AVRKRYWARNF 101
            |:.|.||||||.:||||:||...|||  ....|.|    :..:.:.|..     |:.|..:...|
Human    79 VICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQF 143

  Fly   102 VGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVHGSGYVVKCLSCE 164
                     :|...|:.:...:.:..:....|||:|.|...||  ..::||.||:.|...|:|..
Human   144 ---------KPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSAS 199

  Fly   165 YRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRI-----PECTQCGGDLKPEIVF 224
            .   |||:                          ||.:::. :|     |:|..|...:||:|||
Human   200 C---RHEY--------------------------PLSWMKE-KIFSEVTPKCEDCQSLVKPDIVF 234

  Fly   225 FGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVN 277
            ||:|:|......:.......|.|||:|:||.| ..:..::....|..|..::|
Human   235 FGESLPARFFSCMQSDFLKVDLLLVMGTSLQV-QPFASLISKAPLSTPRLLIN 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	68/248 (27%)
SIRT2	NP_036369.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Nuclear export signal	41..51
		SIRT1	77..331	CDD:238699	68/248 (27%)
		Peptide inhibitor binding	116..120		0/3 (0%)
		Peptide inhibitor binding	232..301		18/56 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810