DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt4 and sir-2.3

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_510220.1	Gene:	sir-2.3 / 185876	WormBaseID:	WBGene00004802	Length:	287	Species:	Caenorhabditis elegans

Alignment Length:	285	Identity:	115/285 - (40%)
Similarity:	179/285 - (62%)	Gaps:	3/285 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHME 85
            ::||||...:.|:.:|:.:..:.:...:|::||||||||||||||||:.||||.::..:|:...:
Worm     3 RKYVPHTTELCENSLKKFKSLVGTVDKLLIITGAGISTESGIPDYRSKDVGLYTKTALEPIYFQD 67

  Fly    86 FVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVE 150
            |:||...|:|||:|:::.||:|:...||..|:||:::|...:...::|||||.||.||||:.:.|
Worm    68 FMKSKKCRQRYWSRSYLNWPRFAQALPNFNHYALSKWEAANKFHWLITQNVDGLHLKAGSKMITE 132

  Fly   151 VHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKD---APDMIRPDGDVEIPLEYIENFRIPECT 212
            :||:...|||.||||...|..:|..|...||.||:   :|.....|.|..:||...:.|:||||.
Worm   133 LHGNALQVKCTSCEYIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECL 197

  Fly   213 QCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVN 277
            .|||.:|.::..||:::...::......|...:|:|.||:||.|.|||::|........|:.|||
Worm   198 NCGGLMKTDVTLFGENLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAHMQNKPIFIVN 262

  Fly   278 IGETRADHLADIKISAKCGDVIPKL 302
            ||.||||.:|.:|:..:..||:.::
Worm   263 IGPTRADQMATMKLDYRISDVLKEM 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	108/263 (41%)
sir-2.3	NP_510220.1	SIRT4	20..284	CDD:238700	108/263 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162166
Domainoid	1	1.000	214	1.000	Domainoid score	I1586
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8164
Inparanoid	1	1.050	267	1.000	Inparanoid score	I1865
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56570
OrthoDB	1	1.010	-	-		D1407693at2759
OrthoFinder	1	1.000	-	-		FOG0005863
OrthoInspector	1	1.000	-	-		otm14080
orthoMCL	1	0.900	-	-		OOG6_103918
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770