Protein Alignment Sirt4 and sirt5

DIOPT Version :10

• Sequence 1: NP_572241.2
• Gene: Sirt4 / 31480
• FlyBaseID: FBgn0029783
• Length: 312
• Species: Drosophila melanogaster
• Sequence 2: NP_001263631.1
• Gene: sirt5 / 100170199
• XenbaseID: XB-GENE-5892372
• Length: 309
• Species: Xenopus tropicalis
• Alignment Length: 276
• Identity: 88/276 - (31%)
• Similarity: 137/276 - (49%)
• Gaps: 36/276 - (13%)

  Fly    39 EDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHM----EFVKS-SAVRKRYWA 98
            |.|..:| ::.|:||||:|.|||:|.:|  |.|.|.|.  ...||:    .|.:: |.|.:.|..
 Frog    44 EAFAKAK-HIAVITGAGVSAESGVPTFR--GAGGYWRK--WQAQHLATPEAFARNPSRVWEFYHY 103

  Fly    99 RNFVGWPKFSATQPNATHHALA----RFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVK 159
            |..|...|    .||..|.|:|    |..::.|...|:|||:|.||.||||||:.|:|||.:..:
 Frog   104 RREVMLTK----NPNPAHLAIAECETRLRKQGRKLVVITQNIDELHRKAGSRNLFEIHGSLFKTR 164

  Fly   160 CLSCEYRIDRHEFQSILASLNPAF--KDAPDMIRPD-GDVEIPLEYIENFRIPECTQ--CGGDLK 219
            |.||....:.::     :.:.||.  |.||:   || .|.:||:|     ::|.|.:  |.|.|:
 Frog   165 CTSCGSVKENYK-----SPICPALAGKGAPE---PDVQDAKIPVE-----QLPRCDENGCNGLLR 216

  Fly   220 PEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRAD 284
            |.:|:||:::....:.::...:...|..:|:|:|.:|:.......|.....:||...|:..|.|.
 Frog   217 PNVVWFGETLDSNLLGEVEKELEICDLCVVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPAT 281

  Fly   285 HLADIKISAKCGDVIP 300
            ..........||..:|
 Frog   282 TSFTFHFQGPCGTTLP 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	87/273 (32%)
sirt5	NP_001263631.1	SIRT5_Af1_CobB	50..300	CDD:238703	86/270 (32%)