DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pop1 and pop1

DIOPT Version :9

Sequence 1:	NP_572236.3	Gene:	Pop1 / 31475	FlyBaseID:	FBgn0026702	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	XP_021322462.1	Gene:	pop1 / 799016	ZFINID:	ZDB-GENE-120911-1	Length:	777	Species:	Danio rerio

Alignment Length:	754	Identity:	240/754 - (31%)
Similarity:	337/754 - (44%)	Gaps:	143/754 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LPSHVTTYHYAAEALQEIRNLVADCQETTQRSSKLIFQTLPKHMRRRAMSHHPKRLPRKYRQ--- 79
            ||.|:|...:|.....|:..::....:.|  .|..:|..||||||||||||:..|||.:.|.
Zfish    49 LPKHITASFFAGARAAEVSVMLKAVSKPT--GSCQVFTALPKHMRRRAMSHNTHRLPLRLRDAAL 111

  Fly    80 --AHKSQMGKSGNQPVNGKRPSRKYRRRPKNLMREYVRRQRRHVWLETHIWHAKRFHMVDRWGHR 142
              |.:||.|.  .:|...|..||:.|||..:|:.|:.|||||..||||||||||||||.:.|.:|
Zfish   112 RLAERSQRGP--EKPPQAKSRSRRARRRHTHLLLEFNRRQRRSRWLETHIWHAKRFHMQNSWSYR 174

  Fly   143 LPYASCDKTYRACYRASAEHCLLQDISFYGCVELRGPLDMLREGFARLTSPQCGLGITARTFLSG 207
            ||:....|:|||.|||...|.||||:|::.|:||:||.:.:....::|||.|.|....|...|||
Zfish   175 LPHTPTAKSYRASYRAMDTHTLLQDLSYFCCLELQGPEEQILRALSQLTSKQTGPTFAASVCLSG 239

  Fly   208 RREGSVELFEDGRYPYGALQRASFMWRPRREEEDEKQTNHTLWLWLHPSGAQAVLNQLISVFQLK 272
            .|.|.:.|:..|:||:|||....|:||||..|    .|:..||:|:||:..|.||.:|.:|.|
Zfish   240 ARVGRLLLYRAGQYPHGALGPVEFLWRPRAPE----CTHRQLWIWIHPALKQDVLPELQAVCQ-- 298

  Fly   273 STRQQKLPLNEAVTEEKMDVDKIEPVELSKETSPGKKNSKKK--------PEQRPLRFWTKTKAF 329
                    ..|:|.|...........||        :|.|:|        |.:|.|...|:...
Zfish   299 --------CCESVCEVSASSSAAAVDEL--------RNRKRKCTADAAELPAKRLLGDGTRAVG- 346

  Fly   330 DPQPSYFNSDGTLHLVL--LQREFNRFRLTGPRAQKVLFASLRPHREEEL----------QDKAN 382
              .|..:.|..| |:.:  |..|..||||.||.|..||..:|....||.|          |.:.:
Zfish   347 --DPVRWESADT-HITISDLTMEIVRFRLIGPLAHLVLTDTLHAANEEALRGVCVDADLHQQQRD 408

  Fly   383 YCQAALQLSSPAELLSNLVMAHLVVDPRLQRPKKRTKAVGKMEQ---PPLSAGDL-LMNQPKSLP 443
            .......:.|.|||.:..|:...|.||||..|::|.|.|..::.   ....|.|| |...|....
Zfish   409 VFTQLRGVCSTAELPAGCVLGLTVSDPRLTLPQRRGKTVPDLQHISTESSHARDLTLRGVPAHCS 473

  Fly   444 ESPLWSKKARERLAKGIMSAHKYDQLREQHAV-------------------VPGAPCAFE----- 484
            :|.||....|:.:....:|..:.:::|....|                   .||..|..|
Zfish   474 QSALWDTSVRDHVTDSRLSEQELNRVRSDVLVPGSAVCVSGVCAVPLLLLHQPGRVCGQERLRWG 538

  Fly   485 ----------------QQMQ-------------------ALPVILIQRPG---SQDPRYKRLGYG 511
                            |::.                   |:|::|:.:||   .|:    ||.:|
Zfish   539 SGWDLLLPKGWHACVCQELNRVRSDVLVPGSAVCVSGVCAVPLLLLHQPGRVCGQE----RLRWG 599

  Fly   512 CGWDVIAPAGYGMTLWLTLTMWGARPGGLRELDSVAREAGAEIHL----PDTLAGVQRAAASADE 572
            .|||::.|.|:.|..|:.|...|.|.||| .:.....:..|:.|.    ||..||.:..:....|
Zfish   600 SGWDLLLPKGWAMAFWVPLVYRGVRVGGL-HMSVKHAQFMAQPHFPHDYPDCPAGERCQSEQEAE 663

  Fly   573 LRARYFRMPPNKRTNYRKLAVVSPFTAPWRHLVRDWRASFSSASEGSS------FYVLRH---RQ 628
            |..::.|.||:|||||.|...|:||..||:.||.:|........|..|      |.|||.   .:
Zfish   664 LLEKFKRRPPSKRTNYVKHGCVAPFRCPWQQLVDEWAELVELGGETQSRAGPVQFTVLRSVSVLR 728

  Fly   629 QLEEIVESIRHRSPLPQTL----PDDAIIQIQLQLLSRG 663
            ||.....|....:|.....    ...|::.::|:||.:|
Zfish   729 QLSAWCSSASAVTPAAAAALHQEQQGALLWVRLRLLGKG 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pop1	NP_572236.3	POP1	33..178	CDD:284413	72/149 (48%)
Pop1	NP_572236.3	POPLD	514..600	CDD:285393	32/89 (36%)
pop1	XP_021322462.1	POP1	58..211	CDD:311124	73/156 (47%)
pop1	XP_021322462.1	POPLD	601..692	CDD:311891	33/91 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41000
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D341931at33208
OrthoFinder	1	1.000	-	-		FOG0004822
OrthoInspector	1	1.000	-	-		oto38619
orthoMCL	1	0.900	-	-		OOG6_103108
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3405
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.820