DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pop1 and popl-1

DIOPT Version :9

Sequence 1:	NP_572236.3	Gene:	Pop1 / 31475	FlyBaseID:	FBgn0026702	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_498408.1	Gene:	popl-1 / 175911	WormBaseID:	WBGene00015486	Length:	752	Species:	Caenorhabditis elegans

Alignment Length:	871	Identity:	214/871 - (24%)
Similarity:	346/871 - (39%)	Gaps:	207/871 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AEALQEIRNLVADCQETTQRSSKLIFQTLPKHMRRRAMSHHPKRLPRKYRQ---AHK-SQMGKSG 89
            |:.|:.|.|......|.| :..:...|.||:|||||||::..:|.||..|:   ||. |:..|
Worm    17 AQLLKAIDNDALVSGEVT-KGPRTAAQRLPRHMRRRAMAYDIRRFPRTMREFAAAHLISKHAK-- 78

  Fly    90 NQPVNGKRPSRKYRRRPKNLMREYVR-RQRRHVWLETHIWHAKRFHMVDRWGHRLPYASCDKTYR 153
                  |.|||..||:..|...::.| ...:.:||.||:||||||.|:.:||.:|...|..:.:|
Worm    79 ------KCPSRFARRKSANSRTKFGRSTSTKGIWLSTHVWHAKRFRMIQKWGFKLADRSFQRGFR 137

  Fly   154 ACYRASAEHCLLQDISFYGCVELRGPLDMLREGFARLTS-PQCGL-GITARTFLSGRREGSVELF 216
            |..|.|.::|:::|.|:|.||.::     ..:.:::::. .|.|. |.::|    ...|...:|:
Worm   138 AVLRDSNKNCVIRDRSYYTCVTIQ-----CTDAYSKISQFSQKGCRGQSSR----DEEEECHQLY 193

  Fly   217 EDGRYPYGALQRASFMWRPRREEEDEKQTNHTLWLWLHPSGAQAVLNQLISVFQLKSTRQQKLPL 281
            ..|:||:|.:..|.|          ::.:...:.:|:|||.....:..|:..:.|:  :|:.
Worm   194 MPGKYPFGYIGPARF----------QRLSGDKVHIWIHPSSKLQFMKALLEYYNLE--KQEN--- 243

  Fly   282 NEAVTEEKMDVDKIEPVELSKETSPGKKNSKKKPEQRPLRFWTKTKAFDPQPSYFNSDGTLHLVL 346
                |||.:                 .|||:.|                              |.
Worm   244 ----TEEDL-----------------YKNSEIK------------------------------VS 257

  Fly   347 LQRE-FNRFRLTGPRAQKVLFASLRPHREEELQDKANY----CQAALQLSSPAELLSNLVMAHLV 406
            :..| ..||.|:||:....|..|:|...:|:...:.||    ..:..|.|...|:: ||    |:
Worm   258 IDAENICRFHLSGPKCLSKLRDSIRFVNDEKFSSEHNYFLSVSDSVFQSSRDGEVI-NL----LI 317

  Fly   407 VDPRLQRPKK---RTKAVGKMEQPPLSAGDLLMNQPKSLPESPLWSKKARERLAKGIMS---AHK 465
            .|||....:|   :.|.|.|..            ..:.:..|..|:|:.||...:..|:   .||
Worm   318 EDPRTTWDRKTVLKHKKVNKEA------------DNERIRVSKFWNKEFREMAIEKRMADSEFHK 370

  Fly   466 YDQLREQHAVVPGAPCAFEQQMQALPVILIQRPGSQDPRYKRLGYGCGWDVIAPAGYGMTLWLTL 530
            .:..:....:...|         .:|:|||.|    :...|.|.   |.|::.|..:....|::|
Worm   371 QNSSKINGVISTEA---------KVPIILIIR----NEGLKALD---GADILIPEPFAKDFWVSL 419

  Fly   531 TMWGARPGGLRE--------------LDSVAREAGAEIHLPDTLAGVQRAAASADELRARYFRMP 581
            ...|.|..|||:              ||.|..|||.|..|           |...||..:|...|
Worm   420 QRRGVRASGLRDEYAAHLESKALYYPLDDVGSEAGRESEL-----------AMKKELIEKYLGKP 473

  Fly   582 PNKR-TNYRKLAVVSPFTAPWRHLVRDWRASFSSASEGSSFYVLRHRQQLEEIVESIRHRSPLPQ 645
            .|:| .::..::|..||...|..|.:||..|....||.   :|.|..|:|..|.|:::..|.|.:
Worm   474 HNRRCKHWSAVSVKYPFEFKWDELSQDWNLSNKPRSEA---FVCRDLQKLRIIEEAMKKGSGLEE 535

  Fly   646 TLPDDAIIQIQLQLLSRGHVKDNALICLPTAAD----HKKRWRQLKHNDQAPVHVEPTQPDLNEQ 706
            ......:|.::||...||..|...::||||..|    .|.|.|::   .|.|........|:.|.
Worm   536 FQEPGMLIPVKLQFFGRGRPKKYGMVCLPTDDDLISIRKNRNREI---IQTPPEASSQDSDIVEA 597

  Fly   707 LR--------------KELRQSHK-LKLKRLRSRRVREKRRLQETATKRVHIRPANTAHLVRGQL 756
            :.              .|...|.| :.||.|    ..|..:|.:..|||..:.........|.::
Worm   598 MEIEEITVKKNQGFMSLEAAASEKPINLKLL----FEETTKLDDKTTKRKRVNRKKRESKKRRKI 658

  Fly   757 QEMCRLWLPTDPAELRD------SVRRQCSRQVFGYVSTAGFSFTEALVCAVGYVTPAGLQQLIE 815
            ::..|    .:.||:.:      ..|...:|::.|.:.....|........:||:....|..:..
Worm   659 EQEKR----KEEAEVEEVQKLATKYRFSANREIIGRLVAGEQSVLAGHGVGIGYICANTLSLIAS 719

  Fly   816 ELPASKGNRKQPPLMCLVRDADSRDY 841
            ....||       .:.:||::.|:.|
Worm   720 NYHKSK-------TVVMVRNSTSKYY 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pop1	NP_572236.3	POP1	33..178	CDD:284413	55/149 (37%)
Pop1	NP_572236.3	POPLD	514..600	CDD:285393	27/100 (27%)
popl-1	NP_498408.1	POP1	8..161	CDD:284413	57/152 (38%)
popl-1	NP_498408.1	POPLD	404..492	CDD:285393	27/98 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158662
Domainoid	1	1.000	67	1.000	Domainoid score	I6475
eggNOG	1	0.900	-	-		E1_KOG3322
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2844
Isobase	1	0.950	-	0	Normalized mean entropy	S6514
OMA	1	1.010	-	-		QHG50054
OrthoDB	1	1.010	-	-		D341931at33208
OrthoFinder	1	1.000	-	-		FOG0004822
OrthoInspector	1	1.000	-	-		oto20513
orthoMCL	1	0.900	-	-		OOG6_103108
Panther	1	1.100	-	-	LDO	PTHR22731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R951
SonicParanoid	1	1.000	-	-		X3405
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750