DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlc-c and MYL1

DIOPT Version :9

Sequence 1:	NP_001245533.1	Gene:	Mlc-c / 31474	FlyBaseID:	FBgn0004687	Length:	153	Species:	Drosophila melanogaster
Sequence 2:	NP_524144.1	Gene:	MYL1 / 4632	HGNCID:	7582	Length:	194	Species:	Homo sapiens

Alignment Length:	141	Identity:	77/141 - (54%)
Similarity:	98/141 - (69%)	Gaps:	4/141 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EEFQEAFNLFDNRGDGKIQLSQVGECLRALGQNPTESDVKKCTHQLKPDE----RISFEVFLPIY 76
            :||:|||.|||..||.||.|||||:.|||||.|||.::|:|.......:|    :|.||.|||:.
Human    53 DEFKEAFLLFDRTGDSKITLSQVGDVLRALGTNPTNAEVRKVLGNPSNEELNAKKIEFEQFLPMM 117

  Fly    77 QAISKARSGDTADDFIEGLRHFDKDASGYISSAELRHLLTTLGEKLTDEEVEQLLANMEDQQGNI 141
            ||||..:...|.:||:||||.|||:.:|.:..|||||:|.|||||:.:||||.|:|..||..|.|
Human   118 QAISNNKDQATYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCI 182

  Fly   142 NYEEFVRMVMS 152
            |||.||:.:||
Human   183 NYEAFVKHIMS 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlc-c	NP_001245533.1	PTZ00184	14..152	CDD:185504	75/139 (54%)
MYL1	NP_524144.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		PTZ00184	45..193	CDD:185504	75/139 (54%)
		EFh	54..118	CDD:298682	34/63 (54%)
		EF-hand_6	54..83	CDD:290141	20/28 (71%)
		EFh	131..192	CDD:238008	36/60 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159936
Domainoid	1	1.000	45	1.000	Domainoid score	I12220
eggNOG	1	0.900	-	-		E2759_KOG0030
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4230
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52059
OrthoDB	1	1.010	-	-		D1470794at2759
OrthoFinder	1	1.000	-	-		FOG0000359
OrthoInspector	1	1.000	-	-		otm40563
orthoMCL	1	0.900	-	-		OOG6_103928
Panther	1	1.100	-	-	O	PTHR23048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4661
SonicParanoid	1	1.000	-	-		X268
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840