DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlc-c and MYL6B

DIOPT Version :9

Sequence 1:	NP_001245533.1	Gene:	Mlc-c / 31474	FlyBaseID:	FBgn0004687	Length:	153	Species:	Drosophila melanogaster
Sequence 2:	NP_001186558.1	Gene:	MYL6B / 140465	HGNCID:	29823	Length:	208	Species:	Homo sapiens

Alignment Length:	142	Identity:	78/142 - (54%)
Similarity:	101/142 - (71%)	Gaps:	4/142 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LEEFQEAFNLFDNRGDGKIQLSQVGECLRALGQNPTESDVKKCTHQLKPDE----RISFEVFLPI 75
            ||||:|||.|||..|||||..||.|:.:||||||||.::|.|.....|.||    |:.||.|||:
Human    66 LEEFKEAFELFDRVGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELKSRRVDFETFLPM 130

  Fly    76 YQAISKARSGDTADDFIEGLRHFDKDASGYISSAELRHLLTTLGEKLTDEEVEQLLANMEDQQGN 140
            .||::|.|...|.:|::||.|.|||:.:|.:..|||||:|||||||:|:||||.:||..||..|.
Human   131 LQAVAKNRGQGTYEDYLEGFRVFDKEGNGKVMGAELRHVLTTLGEKMTEEEVETVLAGHEDSNGC 195

  Fly   141 INYEEFVRMVMS 152
            ||||.|::.::|
Human   196 INYEAFLKHILS 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlc-c	NP_001245533.1	PTZ00184	14..152	CDD:185504	77/140 (55%)
MYL6B	NP_001186558.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		PTZ00184	58..207	CDD:185504	77/140 (55%)
		EFh	68..132	CDD:298682	35/63 (56%)
		EFh	68..96	CDD:197492	17/27 (63%)
		EFh	150..205	CDD:238008	32/54 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0030
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4230
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52059
OrthoDB	1	1.010	-	-		D1470794at2759
OrthoFinder	1	1.000	-	-		FOG0000359
OrthoInspector	1	1.000	-	-		otm40563
orthoMCL	1	0.900	-	-		OOG6_103928
Panther	1	1.100	-	-	O	PTHR23048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4661
SonicParanoid	1	1.000	-	-		X268
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910