Protein Alignment RhoGAP5A and SYDE1

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_149014.3
• Gene: SYDE1 / 85360
• HGNCID: 25824
• Length: 735
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 133/574 - (23%)
• Similarity: 189/574 - (32%)
• Gaps: 203/574 - (35%)

  Fly     4 NTEAGAGNANTGGSGGV------------GGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRT 56
            :|..|.|...||...|.            ..||||..|.....:.|....|..|||..|.:..||
Human    93 DTSLGPGVPGTGEPAGEIWYNPIPEEDPRPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRT 157

  Fly    57 LPLPPA-------KSTAEAVEANNLAGRLYG-------------SEYH----------------- 84
            ....||       |...|.....:|.|...|             |.||
Human   158 KSPGPARRLSIKMKKLPELRRRLSLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGT 222

  Fly    85 -----GLMGHLEAEQLLANARDGSYF-------VRRSPQSDGYYTLSLRF----NKRPKHYKLLY 133
                 |.:...::.:..|.....:.|       ..|:|.:..:..|||..    ..||
Human   223 RSPRAGYLSDGDSPERPAGPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRP------- 280

  Fly   134 KPG-------------------VGHYLRGQD-KRFDTVHDMVADGLINFHMQLHASPIIQQINQQ 178
            .||                   .|....|.| .|.|  |        .||::|.|:
Human   281 APGATPRDLCCLLQVDGEARARTGPLRGGPDFLRLD--H--------TFHLELEAA--------- 326

  Fly   179 TKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHH 243
                           |.||||              ..|.:...::..|.......:|.|:.
Human   327 ---------------RLLRAL--------------VLAWDPGVRRHRPCAQGTVLLPTVFR---- 358

  Fly   244 FKVHTFKGLNWCEFCANFLWGFTAQ--GVKCEACGFVAHSKCS----ELVPPKCVPDLKRIRGVF 302
                                |..||  .|:.|..|.: ::|.:    :..|....|      .||
Human   359 --------------------GCQAQQLAVRLEPQGLL-YAKLTLSEQQEAPATAEP------RVF 396

  Fly   303 GTDLTTMVQLE-PHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMS 366
            |..|..:|:.| |..|:|.::::||.::|.||:...|:||:.|.|...:.|:.|.:|:.....:|
Human   397 GLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLS 461

  Fly   367 ETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHH--- 428
            |..|.::|||.|.||.|||.||.||||...|...:.|           :..:...|:||...
Human   462 EDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEA-----------MARDPPNRVPPTTEGTR 515

  Fly   429 ---SC--------LQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMT 471
               ||        |..:|:||:.|:|.:|.|:|...|||..|.|.|:...|..|
Human   516 GLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPT 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	25/156 (16%)
		C1_1	242..294	CDD:278556	8/57 (14%)
		RhoGAP_chimaerin	302..491	CDD:239837	63/185 (34%)
SYDE1	NP_149014.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..253		32/159 (20%)
		RhoGAP	396..601	CDD:295372	63/185 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..651
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..696

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920