DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and RGA2

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_010667.1	Gene:	RGA2 / 851985	SGDID:	S000002787	Length:	1009	Species:	Saccharomyces cerevisiae

Alignment Length:	459	Identity:	99/459 - (21%)
Similarity:	176/459 - (38%)	Gaps:	106/459 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 LEAEQLLANARDGSYFVRRSPQSDGYYT-LSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHD 153
            ||.:....:|.|.|   ..|.:.|.|:| |:||      ..||..:.     |.|..|:.  :.|
Yeast   597 LEDDSTKVDATDES---ATSLEKDFYFTELTLR------KLKLDVRE-----LEGTKKKL--LQD 645

  Fly   154 MVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEE 218
            :.       :::|....::..::..|:...:||    .:.|:.......:..:...:|..|.::.
Yeast   646 VE-------NLRLAKERLLNDVDNLTREKDKQS----ASSRESLEQKENIATSITVKSPSSNSDR 699

  Fly   219 KEQKQEEPPPPAVDPMPLVYEKPHHFKV------HTFKGLNWCEFCANFLWGFTAQGVKCEACGF 277
            |.......|            ||..:|:      |....|...:...|...|.|..
Yeast   700 KGSISNASP------------KPRFWKIFSSAKDHQVGDLESQQRSPNSSSGGTTN--------- 743

  Fly   278 VAHSKCS---------ELVPPKCV---PDLKRI------RGVFGTDLTTMVQLEPHHQIPFVVRR 324
            :|..:.|         ||..|..|   |..||:      ..::|:.|......| ...:|.::|.
Yeast   744 IAQKEISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYE-KSTVPIIIRC 807

  Fly   325 CVEEVEAR--GMLQEGIYRVSG---FADEIE---ALKLALDREGEKTDMSETAYGNVNVIAGTLK 381
            |::.:|..  |:..||:||.||   ..:|||   |...:|..:.....::.....:::.:|..||
Yeast   808 CIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLK 872

  Fly   382 LYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQL---------------------MAEAVRRLPP 425
            .|||.||.|:::|..|.:.:...|..:..|:..|                     :.|..:.||.
Yeast   873 RYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPV 937

  Fly   426 AHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIAT---PQHMTNLTEEIFMLSSLITHC 487
            .|...|:.:..|:.:|......|.||.|||:.||||:||..   .:.:.::.|..:::..::.:.
Yeast   938 EHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIHDFDGEKDIVDMKERNYIVEFILGNY 1002

  Fly   488 KTIF 491
            :.||
Yeast  1003 RDIF 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	18/76 (24%)
		C1_1	242..294	CDD:278556	12/69 (17%)
		RhoGAP_chimaerin	302..491	CDD:239837	53/220 (24%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781
		RhoGAP	815..1002	CDD:214618	46/186 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	1	1.000	-	-		otm46684
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860