DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and ROPGAP3

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_850458.1	Gene:	ROPGAP3 / 819283	AraportID:	AT2G46710	Length:	455	Species:	Arabidopsis thaliana

Alignment Length:	210	Identity:	54/210 - (25%)
Similarity:	92/210 - (43%)	Gaps:	26/210 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 SEL---VPPKCVPDLKRIRGVFGTDLTTMVQL---EPHHQIPFVVRRCVEEVEARGMLQ-EGIYR 341
            |||   |||: .|...  ..|||....:| |.   :..:.:|.::.|..:.:...|.|: |||:|
plant   130 SELEPEVPPR-APSAS--VSVFGVSAKSM-QCSYDDRGNSVPTILLRMQKRLYTEGGLKAEGIFR 190

  Fly   342 VSGFADEIEALKLALDREGEKTDMSETAYG-NVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGR 405
            ::....:.|.::..|       :......| :|:.:||.:|.:.|.||..::........|   |
plant   191 INPDNGKEEHVRRQL-------NCGVVPRGIDVHCLAGLIKAWFRELPTGVLDVLTPEQVM---R 245

  Fly   406 TGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHM 470
            ...:.:..:|    |..|||...:.|.:.:..:..|..|...||||..|:|.||||.:......:
plant   246 CNTEEDCSRL----VILLPPVESAILDWAIGLMADVVEHEQFNKMNARNVAMVFAPNMTQMADPL 306

  Fly   471 TNLTEEIFMLSSLIT 485
            |.|...:.:::.|.|
plant   307 TALIHAVQVMNFLKT 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	6/12 (50%)
		RhoGAP_chimaerin	302..491	CDD:239837	46/189 (24%)
ROPGAP3	NP_850458.1	CRIB	103..143	CDD:238077	7/13 (54%)
ROPGAP3	NP_850458.1	RhoGAP	167..323	CDD:238090	42/169 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910