DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and si:dkey-33c9.6

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021327566.1	Gene:	si:dkey-33c9.6 / 795086	ZFINID:	ZDB-GENE-130530-592	Length:	829	Species:	Danio rerio

Alignment Length:	204	Identity:	74/204 - (36%)
Similarity:	112/204 - (54%)	Gaps:	14/204 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 FVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYR 341
            :|.|    .|.||...|.|:  ..||...: ..|.::....:|.:||.||||||.||:.:|||||
Zfish   605 YVPH----PLEPPSTTPILQ--EPVFCVPI-GQVAMQESVLVPHIVRSCVEEVERRGLKEEGIYR 662

  Fly   342 VSGFADEIEALKLALD---REGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAA 403
            :||.:.||:|||.|.:   ||.    :|:....:||.::||||||.|.||:|||..:.:.....|
Zfish   663 ISGASTEIQALKYAFNTNYREA----VSKLRSVDVNAVSGTLKLYFRELPLPLIPCEHFSELSDA 723

  Fly   404 GRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQ 468
            ........:...:...::.||..:.:.|.::|.||:|||.....|||:..||||||.|:|:..|.
Zfish   724 LDIADPFVRADSLLSLLQSLPDVNRNTLLFLLHHLRRVAERKEENKMSLSNLATVFGPSLLRPPV 788

  Fly   469 HMTNLTEEI 477
            ...::::|:
Zfish   789 SRVDISQEV 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	5/16 (31%)
		RhoGAP_chimaerin	302..491	CDD:239837	66/179 (37%)
si:dkey-33c9.6	XP_021327566.1	RhoGEF	71..281	CDD:214619
		PH-like	297..453	CDD:327399
		C2	495..605	CDD:326325	74/204 (36%)
		RhoGAP	624..812	CDD:295372	66/179 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910