Protein Alignment RhoGAP5A and Arhgap10

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_084389.2
• Gene: Arhgap10 / 78514
• MGIID: 1925764
• Length: 786
• Species: Mus musculus
• Alignment Length: 497
• Identity: 115/497 - (23%)
• Similarity: 197/497 - (39%)
• Gaps: 136/497 - (27%)

  Fly    93 EQLLANARDGSYFVRRSPQS----DGYYTLSLRFNKRPKHY-----------KLLYKPGVGHYLR 142
            |||.|...:...|.:.:.::    |.:.|||.|  |:..|.           :..|:..:.:..:
Mouse   122 EQLGAVKEEKKKFDKETEKNYSLIDKHLTLSAR--KKDSHLQEADLQVEQNRQHFYELSLEYVCK 184

  Fly   143 GQD----KRFDTVHDMVA--DGLINFHMQLHA-------SPIIQQIN-QQTKNCYQQSPYMTLNG 193
            .|:    |:|:.|..|::  .|:..|:.|.|.       ..:..||| |.|:|.::.:      .
Mouse   185 LQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGT------R 243

  Fly   194 RKLRALSNELGKAAAKESKESPAEEKEQK----------QEEPPPPA----VDPMPLVYEKPHHF 244
            .::..|.|::        :::|.::|...          ||:.|.|.    |....:..:....|
Mouse   244 SEVEELMNKI--------RQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKF 300

  Fly   245 KVHTFKG-------------LNWC----------EFCANF-----------LWGFTAQGVK--CE 273
            .:..|:.             |..|          .||.:.           :..|:.:..|  .|
Mouse   301 NMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLE 365

  Fly   274 ACG---FVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPF-VVRRCVEEVEARGM 334
            |.|   .:.|:....:||        |..|  |..|..|         .| ::|:|:..||.||:
Mouse   366 ALGGKEALFHTFNRAIVP--------RPEG--GAQLDKM---------GFTILRKCISAVETRGI 411

  Fly   335 LQEGIYRVSGFADEIE-ALKLALD-REGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAY 397
            ..:|:|||.|.:.::: .|.:.:| :...:.|:..:|...|..:...||.|||.||.||:|::.:
Mouse   412 NDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELH 476

  Fly   398 PSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPT 462
            ..|:...::|....:...:...|.:||..:...|..:::||..|:||...|.|...||..||.||
Mouse   477 RDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPT 541

  Fly   463 LIATPQHMT----------NLTEEIFMLSSLITHCKTIFATS 494
            |: .||..|          |:..||     ||.:.:.||.||
Mouse   542 LM-RPQEETVAAIMDLKFQNIVVEI-----LIENHEKIFRTS 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	20/93 (22%)
		C1_1	242..294	CDD:278556	14/90 (16%)
		RhoGAP_chimaerin	302..491	CDD:239837	58/201 (29%)
Arhgap10	NP_084389.2	BAR	19..225	CDD:299863	22/104 (21%)
		BAR-PH_GRAF_family	267..372	CDD:269953	16/104 (15%)
		PH	269..367	CDD:278594	14/97 (14%)
		RhoGAP_Graf	367..569	CDD:239839	64/226 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..609
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..714
		SH3_GRAF2	732..785	CDD:212998

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940