DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and abr

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_012812699.1	Gene:	abr / 779766	XenbaseID:	XB-GENE-5797083	Length:	1019	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	131/474 - (27%)
Similarity:	197/474 - (41%)	Gaps:	129/474 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WKPELYKLQ---LEAPAPCPLRCQ---------RTLPLPPAKSTAEAVEANNLAGRLYGSEYHGL 86
            |:..:.|||   |:|.|..|...|         ||:...|..|..:            ..|..||
Frog   610 WREAIQKLQKKDLQALALSPFELQVLTASCFKLRTVHNVPIISHKD------------DDESPGL 662

  Fly    87 MGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRF--D 149
            .|.|..  ::.:|:..|:      .|:.|.||.:              ...|:::.....|.  |
Frog   663 YGFLHV--IVKSAKGFSH------SSNLYCTLEV--------------DSFGYFVSKAKTRVFRD 705

  Fly   150 TVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNE-----LGKAAAK 209
            |......:   .|.::|..|..::.:..:  .||.:|        ||...:||     :||...:
Frog   706 TTEPEWNE---EFEIELEGSQCLRILCYE--KCYDKS--------KLNKDNNEIVDKIMGKGQIQ 757

  Fly   210 ESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEA 274
                                 :||. :|..|..|..|....|:. .||...|
Frog   758 ---------------------LDPQ-VVQSKNWHDDVIEMNGIK-VEFSMKF------------- 786

  Fly   275 CGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGI 339
                    .|..:..|..|. |:..||||..::.:.:.| ..::|::||:|:||||.||:.:.||
Frog   787 --------SSRDMSLKRTPS-KKQTGVFGVKISVVTKRE-RSKVPYIVRQCIEEVEKRGIEEVGI 841

  Fly   340 YRVSGFADEIEALKLALDREGEK-----TDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPS 399
            ||:||.|.:|:|||.:.|...:.     :||      ::|.||||||||.|.||.||:|.:.|.:
Frog   842 YRISGVATDIQALKASFDANSKDILMMLSDM------DINAIAGTLKLYFRELPEPLLTDRLYLA 900

  Fly   400 FMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI 464
            ||........|.:...|...:|.||..:.....::|:||||||....:|||:.|||||||.|||:
Frog   901 FMEGIALSDPAAKENCMMHLLRSLPDPNLMTFLFLLQHLKRVAEKEPINKMSLHNLATVFGPTLL 965

  Fly   465 ATPQ-----HMTNLTEEIF 478
            ...:     || ||..:|:
Frog   966 RPSEVESKGHM-NLASDIW 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	16/92 (17%)
		C1_1	242..294	CDD:278556	8/51 (16%)
		RhoGAP_chimaerin	302..491	CDD:239837	75/187 (40%)
abr	XP_012812699.1	Bcr-Abl_Oligo	3..65	CDD:312543
		RhoGEF	254..442	CDD:214619
		PH_ABR	436..620	CDD:270172	4/9 (44%)
		C2_ABR	666..786	CDD:176068	32/177 (18%)
		RhoGAP_Bcr	805..1000	CDD:239852	75/187 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940