DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap27

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_002933206.3	Gene:	arhgap27 / 779583	XenbaseID:	XB-GENE-982958	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	509	Identity:	115/509 - (22%)
Similarity:	198/509 - (38%)	Gaps:	124/509 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTL 118
            |.:||.....|.....:.||:..:|. ..|..:....:.|       |..:.:||:...|   .|
Frog   572 QWSLPRIGPASLHRPNDDNNVFTKLQ-DNYPAITARKDTE-------DFGHRLRRAGSED---FL 625

  Fly   119 SLRFNKRPKHYKLLYKPGVGHYLRGQD------KRFDTVHDMVADGLINF-------------HM 164
            ::..:..|...|.|.|.||.|..:..|      |.:.:...::..|::.|             |.
Frog   626 NVGGDHHPHQTKSLEKAGVLHKAKISDNGKKLRKSWSSSWTVLEGGILTFFRDGKNLSSNSSRHS 690

  Fly   165 QLHA-------------------SPIIQQINQQTKNCYQQSPYM------TLNGRKLRALSNELG 204
            ||..                   |.....:..:|:|   .|.|:      |:......::.|.:.
Frog   691 QLSTPEYTVRLEGASLVWATKDKSSKKHVLELKTRN---GSEYLIHHDSETITADWHESIKNSIA 752

  Fly   205 KAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQ- 268
            :.....:..:|.:|.|..||                                      :|.|.:
Frog   753 RNIRVSADHTPEDEPEPFQE--------------------------------------FGSTEKL 779

  Fly   269 GVKCE----ACGFVAHSKCSELVPPKCVPDLK--------RIRG-----VFGTDLTTMVQLEPHH 316
            |.|.|    :.|..::|.....|..|....|:        |.||     |||..|..:.:.|..:
Frog   780 GTKDEKKNSSMGSGSNSDSDRKVRAKLKKFLQRRPTIQSLRDRGYIKEQVFGCPLQQLCEREKQN 844

  Fly   317 QIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLK 381
             :|..||:.::.||.||:..:|:|||||....|:.|:..:|:| |.|::.:..:.:|:||.|.||
Frog   845 -VPDFVRKAIQAVEKRGLDIDGLYRVSGNLATIQKLRHKVDQE-ENTNLEDGRWEDVHVITGALK 907

  Fly   382 LYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYA 446
            |:.|.||.||..|..:..|:...:....|.:::...|.::.|||.:...:|::..||.:|.....
Frog   908 LFFRELPEPLFPFSHFDMFIETIKLNDPALKKKQFKELIQSLPPPNQETMQFLFRHLCKVIECKD 972

  Fly   447 VNKMNEHNLATVFAPTLIATPQHMTNLTEEIFM------LSSLITHCKTIFATS 494
            .|:|:..::|.||.|||:.......|:.  ::|      :..:::..|.||.||
Frog   973 SNRMSIQSVAIVFGPTLLRPSIEGANIA--MYMVFQNQIVEQVLSQYKYIFNTS 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	20/109 (18%)
		C1_1	242..294	CDD:278556	9/56 (16%)
		RhoGAP_chimaerin	302..491	CDD:239837	57/194 (29%)
arhgap27	XP_002933206.3	SH3_ARHGAP27	11..67	CDD:213002
		PHA03247	<91..489	CDD:223021
		WW	434..460	CDD:395320
		PH_ARHGAP9-like	640..753	CDD:270053	18/115 (16%)
		RhoGAP_ARHGAP27_15_12_9	830..1016	CDD:239868	56/189 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010