DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap12

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006526377.1	Gene:	Arhgap12 / 75415	MGIID:	1922665	Length:	843	Species:	Mus musculus

Alignment Length:	481	Identity:	110/481 - (22%)
Similarity:	198/481 - (41%)	Gaps:	122/481 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LPLPPAKSTAEAVEANNLAGRLYGSEYHGLM--------------------GHLEAEQLLANARD 101
            |.||..:|...:.:..:.||.|.|.|.:||:                    ..|:...||.....
Mouse   437 LCLPENESPPTSSKHQDPAGSLKGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQ 501

  Fly   102 G---SYFVRRSPQSDGYYTLSLR----------FNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHD 153
            |   |:|  .|.||...:|:.|:          .:.:...::|..:.|....::..:
Mouse   502 GSSTSWF--GSNQSKPEFTVDLKGAVIEMASKDKSSKKNVFELKTRQGTELLIQSDN-------- 556

  Fly   154 MVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEE 218
               |.:||...::.:|.|..|:                         .|..:||.:|:.:||..|
Mouse   557 ---DAVINDWFKVLSSTINNQV-------------------------AEADEAAEEETPDSPGVE 593

  Fly   219 KEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKC 283
            |..|::              ::....|:.:.||        :.:.....:..|.....|:...
Mouse   594 KHDKEK--------------DQKELKKLRSMKG--------SSMDSSEQKKTKKNLKKFLTRR-- 634

  Fly   284 SELVPPKCVPDLKRIR-------GVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYR 341
                     |.|:.:|       .|||::|..:.|.| :..:|..|:.|:|.||..|:..:||||
Mouse   635 ---------PTLQAVREKGYIKDQVFGSNLANLCQRE-NGTVPKFVKLCIEHVEEHGLDVDGIYR 689

  Fly   342 VSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRT 406
            |||....|:.|:.|::.: ||.|::::.:.:::||.|.||::.|.||.||.||..:..|:.|
Mouse   690 VSGNLAVIQKLRFAVNHD-EKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNA--- 750

  Fly   407 GKQAEQRQLMA--EAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQH 469
            .||..::::.|  :.:|:||..:...:|.:..|||||..:...|:|...::|.||.|||:...:.
Mouse   751 IKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERE 815

  Fly   470 MTNLTEEIF----MLSSLITHCKTIF 491
            ..|:.....    ::..::....|:|
Mouse   816 TGNIAVHTVYQNQIVELILLELSTVF 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	23/123 (19%)
		C1_1	242..294	CDD:278556	5/51 (10%)
		RhoGAP_chimaerin	302..491	CDD:239837	61/194 (31%)
Arhgap12	XP_006526377.1	SH3_ARHGAP12	13..72	CDD:213003
		SH3-WW_linker	69..264	CDD:374675
		PRP40	257..>409	CDD:227435
		WW	266..296	CDD:238122
		PH_ARHGAP9-like	462..573	CDD:270053	21/123 (17%)
		RhoGAP_ARHGAP27_15_12_9	651..836	CDD:239868	60/189 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920