Protein Alignment RhoGAP5A and Chn2

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001157112.1
• Gene: Chn2 / 69993
• MGIID: 1917243
• Length: 468
• Species: Mus musculus
• Alignment Length: 485
• Identity: 187/485 - (38%)
• Similarity: 270/485 - (55%)
• Gaps: 57/485 - (11%)

  Fly     7 AGAGNANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEA 71
            |.:.|::..||.....|.|...|   :||..||:||.|||.|..:.|.|.:...|
Mouse     2 AASSNSSLSGSSVSSDAEEYQPP---IWKSYLYQLQQEAPRPKRIICPREVENRP---------- 53

  Fly    72 NNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPG 136
                 :.||.|:||::...:|::||... :|:|.:|.|.:..|.|||:|||..:..:|:|.:.
Mouse    54 -----KYYGREFHGIISREQADELLGGV-EGAYILRESQRQPGCYTLALRFGNQTLNYRLFHD-- 110

  Fly   137 VGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTL----NGRKLR 197
             |.:..| :|||:::||:|.||||..:::..|:..|.::.  |...|:...|.||    ..|:|.
Mouse   111 -GKHFVG-EKRFESIHDLVTDGLITLYIETKAAEYIAKMT--TNPIYEHIGYATLLREKVSRRLS 171

  Fly   198 ALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLV-------------YEKPHHFKVHTF 249
            ...||..||:....:.:|.|:...              ||             |||.|:||||||
Mouse   172 RSKNESRKASVSNEEHTPVEKISS--------------LVRRAALTHNDNHFNYEKTHNFKVHTF 222

  Fly   250 KGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEP 314
            :|.:|||:||||:||..||||:|..||...|.:||:.||..|.||||||:.|:..||||:|:..
Mouse   223 RGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAH- 286

  Fly   315 HHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGT 379
            :.|.|.||..|:.|:||||:..||:||||||.:.||.:|:|.||:|||.|:|...|.::|:|.|.
Mouse   287 NTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYPDINIITGA 351

  Fly   380 LKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASH 444
            ||||.|.||:|:||:..|..|:.|.:.....|:.:.:.|.:..|||||:..|:|::.|||:|..:
Mouse   352 LKLYFRDLPIPIITYDTYSKFIEAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMN 416

  Fly   445 YAVNKMNEHNLATVFAPTLIATPQHMTNLT 474
            ...|.||..||..||.|||:..|:..|..|
Mouse   417 EKDNLMNAENLGIVFGPTLMRPPEDSTLTT 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	33/90 (37%)
		C1_CHN	241..293	CDD:410356	30/51 (59%)
		RhoGAP_chimaerin	302..491	CDD:239837	77/173 (45%)
Chn2	NP_001157112.1	SH2_a2chimerin_b2chimerin	52..138	CDD:198215	34/105 (32%)
		C1_betaCHN	210..270	CDD:410407	36/59 (61%)
		RhoGAP_chimaerin	275..468	CDD:239837	77/173 (45%)