DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap10

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001038715.1	Gene:	arhgap10 / 692277	ZFINID:	ZDB-GENE-060512-221	Length:	764	Species:	Danio rerio

Alignment Length:	428	Identity:	101/428 - (23%)
Similarity:	161/428 - (37%)	Gaps:	129/428 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 KRFDTVHDMVA--DGLINFHMQ--------LHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALS 200
            |:|:.|..|:|  ..:..|:.|        .|....:|...|.|:|.::.:          |:..
Zfish   192 KKFECVEPMLAFFQTVFTFYHQGYELAKDFDHYKKALQINIQNTRNRFEGT----------RSEV 246

  Fly   201 NELGKAAAKESKESPAEEKEQK----------QEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWC 255
            .||    .|..||||.:.::..          ||:.|||.                    |.:|.
Zfish   247 FEL----MKRIKESPQDYRQTSPISSEGYLYVQEKRPPPF--------------------GSSWV 287

  Fly   256 EFCANFL------------------WGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVF 302
            :..:.|:                  .|.| :.|..::|    ..|.::.:..:...|:: |....
Zfish   288 KRYSTFVKEQKILHMKTFDQRSGGKLGET-ESVTLKSC----VRKTTDALDRRFCLDIE-ITDRP 346

  Fly   303 GTDLTTMVQLEPHHQ---------------------------------IPFVVRRCVEEVEARGM 334
            ||.||.....|..|:                                 |.| |:..:..:||||:
Zfish   347 GTVLTVQALSEDDHKFWMHAMGGKEPMQCLNRTHSRERGIDAQLDDVGISF-VKNSINAIEARGI 410

  Fly   335 LQEGIYRVSGFADEIE-ALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYP 398
            ..:|:|||.|.:.::: .|.|.:|.:....|:|.....:|..|...||||||.||.||:|::.|.
Zfish   411 NDQGLYRVVGVSSKVQKLLSLMIDEKSSDIDLSANEDWDVKTITSALKLYLRSLPEPLMTYELYK 475

  Fly   399 SFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTL 463
            .|:...::.....:.|.:...|.:||..:...|..:.:||..||::...|.|...||..||.|||
Zfish   476 EFIVPAKSASPESRVQAIHCLVHKLPEKNRLVLSLVTKHLANVAANSKQNLMTVANLGVVFGPTL 540

  Fly   464 IATPQHMT----------NLTEEIFMLSSLITHCKTIF 491
            : .||..|          |:..||     ||...:.||
Zfish   541 M-RPQEETVAAIMDLKFQNIVVEI-----LIEQHEKIF 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	7/29 (24%)
		C1_1	242..294	CDD:278556	8/69 (12%)
		RhoGAP_chimaerin	302..491	CDD:239837	64/232 (28%)
arhgap10	NP_001038715.1	BAR_GRAF2	19..225	CDD:153319	8/32 (25%)
		BAR-PH_GRAF_family	267..373	CDD:269953	21/131 (16%)
		PH	269..367	CDD:278594	21/123 (17%)
		RhoGAP	367..566	CDD:295372	57/205 (28%)
		SH3	710..763	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940