DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap19

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_038957347.1	Gene:	Arhgap19 / 679082	RGDID:	1593044	Length:	536	Species:	Rattus norvegicus

Alignment Length:	211	Identity:	58/211 - (27%)
Similarity:	106/211 - (50%)	Gaps:	34/211 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDM 365
            |||:.||.....:.:..|.::         .:.:..||::||.|.:...:.|:.||: .|...|:
  Rat   112 VFGSPLTEEGIAQIYQLIEYL---------HKNLRVEGLFRVPGNSVRQQLLRDALN-NGTDIDL 166

  Fly   366 SETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFM----------AAGRTGKQAEQRQLMAEAV 420
            ....: :.|.:|..||::|..||.||:|.:.:...:          ...:|....::||:  ||:
  Rat   167 DSGEF-HSNDVATLLKMFLGELPEPLLTHKHFHVHLKIADLMQFDDKGNKTNIPDKERQI--EAL 228

  Fly   421 RR----LPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMT--NLTEEIFM 479
            :.    ||||:.:.|:.:|:.|.:.|.....|||:.||||.:|||.:: .|:::|  :|.|.|..
  Rat   229 QLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVL-WPKNVTANDLQENITK 292

  Fly   480 LSS----LITHCKTIF 491
            |::    :|.|.:.:|
  Rat   293 LNTGMAFMIKHSQKLF 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556
		RhoGAP_chimaerin	302..491	CDD:239837	56/208 (27%)
Arhgap19	XP_038957347.1	RhoGAP_ARHGAP19	113..320	CDD:239857	57/210 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900