Protein Alignment RhoGAP5A and ARHGAP9

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001306779.2
• Gene: ARHGAP9 / 64333
• HGNCID: 14130
• Length: 750
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 138/645 - (21%)
• Similarity: 215/645 - (33%)
• Gaps: 234/645 - (36%)

  Fly    11 NANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPL----RCQRTLPLPPAKSTAEAVEA 71
            :|:|.|       |:|              |..|.|..|.|    ||.|:.|..||....:.::|
Human   175 SASTAG-------PQP--------------LMSEPPVYCNLVDLRRCPRSPPPGPACPLLQRLDA 218

  Fly    72 ---------------NNLAG-------RLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDG 114
                           |:|.|       |...||.:  .|.:|..|.|....|     ...||:.|
Human   219 WEQHLDPNSGRCFYINSLTGCKSWKPPRRSRSETN--PGSMEGTQTLKRNND-----VLQPQAKG 276

  Fly   115 YY-------------TLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQL 166
            :.             :|||...........|..|      |...:..|..|::...||:|.
Human   277 FRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAP------RPLPQLLDDPHEVEKSGLLNM---- 331

  Fly   167 HASPIIQQINQQTKN--------------CYQQSP------------------------------ 187
              :.|.|...:..||              .|::.|
Human   332 --TKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGR 394

  Fly   188 ----------YMTLNG-----------------RKLRALSNEL------------GKAAAKESKE 213
                      ..|:.|                 |.||.:...|            |:......:|
Human   395 HLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREAPTGRDQGSGDRE 459

  Fly   214 SPAE--------------EKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWG 264
            :|.|              |.|:::.|     :...||:........:...:|
Human   460 NPLELRLSGSGPAELSAGEDEEEESE-----LVSKPLLRLSSRRSSIRGPEG------------- 506

  Fly   265 FTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRI--RG-----VFGTDLTTMVQLEPHHQIPFVV 322
             |.|.        ...:|...|:..:  |.|:.:  ||     |||..|.::.|.| ...:|..:
Human   507 -TEQN--------RVRNKLKRLIAKR--PPLQSLQERGLLRDQVFGCQLESLCQRE-GDTVPSFL 559

  Fly   323 RRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKT-----------------DMSETAY 370
            |.|:..|:.||:..:|||||||....::.|:..:|||...|                 |:..|.:
Human   560 RLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW 624

  Fly   371 GNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYML 435
            .:::|:.|.|||:||.||.||:.....|.|.||....:..:....:.|.:..:|..:|..|:|:|
Human   625 DDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLL 689

  Fly   436 EHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIF----MLSSLITHCKTIF 491
            |||.||.:|...|:|..|||..||.|||....|..::......    ::..::|:..::|
Human   690 EHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLF 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	23/110 (21%)
		C1_1	242..294	CDD:278556	5/51 (10%)
		RhoGAP_chimaerin	302..491	CDD:239837	64/209 (31%)
ARHGAP9	NP_001306779.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..187		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..319		17/89 (19%)
		Lipid binding	342..345		1/2 (50%)
		Lipid binding	397..399		0/1 (0%)
		Lipid binding	432..669		60/266 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..488		7/46 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920