DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP5A and ARHGAP22

DIOPT Version :10

Sequence 1:NP_727007.1 Gene:RhoGAP5A / 31473 FlyBaseID:FBgn0029778 Length:494 Species:Drosophila melanogaster
Sequence 2:XP_011538304.1 Gene:ARHGAP22 / 58504 HGNCID:30320 Length:720 Species:Homo sapiens


Alignment Length:251 Identity:77/251 - (30%)
Similarity:125/251 - (49%) Gaps:42/251 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 NWCEFCANFLW----GFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLE 313
            :|.:.....:|    |.||:.         :|:...|.:||          |:||..|...|   
Human   141 DWVQAIRRVIWAPLGGGTARR---------SHAHPLEPLPP----------GIFGQRLEETV--- 183

  Fly   314 PHHQ-------IPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYG 371
             ||:       .|.:|.:||:.:..||:.:||::|:.|.|:.:..|:.:.|. |||.....|.  
Human   184 -HHERKYGPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDC-GEKPLFDSTT-- 244

  Fly   372 NVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGR--TGKQAEQRQLMAEAVRRLPPAHHSCLQYM 434
            :|:.:|..||||||.||.|::.|..|..|::..:  |..:.|....:|:.|..||.|:::.|:|:
Human   245 DVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYI 309

  Fly   435 LEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHCKTI 490
            .:.|..|.::..||||:..||||||.|.:: .||....:|  |...:||:.|..|:
Human   310 CKFLDEVQAYSNVNKMSVQNLATVFGPNIL-RPQVEDPVT--IMEGTSLVQHLMTV 362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP5ANP_727007.1 SH2_a2chimerin_b2chimerin 75..166 CDD:198215
C1_CHN 241..293 CDD:410356 9/43 (21%)
RhoGAP_chimaerin 302..491 CDD:239837 67/198 (34%)
ARHGAP22XP_011538304.1 PH_RhoGAP2 42..157 CDD:241529 2/15 (13%)
RhoGAP_ARHGAP22_24_25 173..371 CDD:239855 68/200 (34%)
Smc <612..>702 CDD:440809
Blue background indicates that the domain is not in the aligned region.

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