DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and ARHGAP31

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_065805.2	Gene:	ARHGAP31 / 57514	HGNCID:	29216	Length:	1444	Species:	Homo sapiens

Alignment Length:	177	Identity:	55/177 - (31%)
Similarity:	95/177 - (53%)	Gaps:	6/177 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 LKR--IRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALD 357
            |||  ....||.|||..:: .....:|:|::.|.|.:|..|:: :||||:||....|:.|:....
Human    10 LKRKGAASAFGCDLTEYLE-SSGQDVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEFG 72

  Fly   358 REGEKTDMSETAY-GNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVR 421
            .: :..|::...| .:::.:....|||.|.||.||:|::.|..|..|.....:..|...:...::
Human    73 SD-QCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQ 136

  Fly   422 RLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQ 468
            .|||:|:..|:|::.||..:||..:...|:..|||.|:||.|:.:.:
Human   137 ELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKE 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556
		RhoGAP_chimaerin	302..491	CDD:239837	52/168 (31%)
ARHGAP31	NP_065805.2	RhoGAP_CdGAP	17..211	CDD:239849	52/170 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..427
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..631
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..893
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..1108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1211..1346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920