DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP5A and RhoGAP1A

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	110/478 - (23%)
Similarity:	178/478 - (37%)	Gaps:	145/478 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 AVEANNLAGRLY--GSEYHGLMGHLEAEQLL------------ANARDGSYFV----RRSPQSDG 114
            |:|..|.....:  |.:|...:..||::.:|            ||.:..::|:    .|:...|.
  Fly   961 AMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDS 1025

  Fly   115 YYTLSLRFNKRPKHYKLLYKPG-----------------------VGHYL-RGQDKRFDTVHDMV 155
            ..:|..:.|          .||                       :|.|| |..:.....|.|:
  Fly  1026 ILSLKQKCN----------LPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDL- 1079

  Fly   156 ADGLINFHMQLHASPIIQQINQ------------------QTKNCYQQSP------YMTLNG-RK 195
                   :|.:|....::|.|.                  ..|.|..|:|      .:.|.| :.
  Fly  1080 -------YMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQN 1137

  Fly   196 LRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCAN 260
            :|.|..|     |||                       .||:..| |..|:    .|:|......
  Fly  1138 VRILLYE-----AKE-----------------------RPLLKAK-HILKL----SLSWLTETTQ 1169

  Fly   261 FLWGFTAQGVKCE-----ACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPF 320
                  .:.:|..     .|.|       ..:|.:......:...:||..::.:::.| ...|||
  Fly  1170 ------PKSIKLTETLELGCSF-------RFIPGELFRGSTKPGALFGAKMSQVLKRE-KRDIPF 1220

  Fly   321 VVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTD--MSETAYGNVNVIAGTLKLY 383
            ::..|:.|||.||||:.|.|||||.|.::..||.|.:.:..:.:  :.|.   :::.:.|.||.:
  Fly  1221 IIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREV---DIHSVTGILKTF 1282

  Fly   384 LRLLPVPLITFQAYPSF---MAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHY 445
            ||.||..|.|.|.||.|   .:|.....::.:...:.:....||.|:.:.:..:|:||.||....
  Fly  1283 LRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKE 1347

  Fly   446 AVNKMNEHNLATVFAPTLIATPQ 468
            ..|||:.||||.||.|||:...|
  Fly  1348 TDNKMSLHNLAMVFGPTLLRPGQ 1370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	21/132 (16%)
		C1_1	242..294	CDD:278556	8/56 (14%)
		RhoGAP_chimaerin	302..491	CDD:239837	60/172 (35%)
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174	15/85 (18%)
		C2	1079..1187	CDD:301316	26/161 (16%)
		RhoGAP	1203..1398	CDD:295372	60/172 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46684
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940