Protein Alignment RhoGAP5A and RhoGAP19D

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_061502159.1
• Gene: RhoGAP19D / 5666818
• VectorBaseID: AGAMI1_014188
• Length: 2337
• Species: Anopheles gambiae
• Alignment Length: 541
• Identity: 115/541 - (21%)
• Similarity: 194/541 - (35%)
• Gaps: 196/541 - (36%)

  Fly    23 APEPSSPV----------QKVWKPELYKLQLEAPAPCPL---------------RCQRTLPL--- 59
            :|||...:          ....:..::||...|.:.|||               |.|....|
Mosquito  1190 SPEPCGTIDLTNFHVTEGNYTKRKNVFKLTTAAGSYCPLEAAAAAGFGGHAEVHRTQSASGLATV 1254

  Fly    60 ----PPAKSTAEAVEANNLAGRLYGSE--------YHGLM-GHLEAEQLLANARDGSYFVRRSPQ 111
                |.:.:.|.:|.:.:.|| |.|||        .||.| |.:|:.:|:.    ||.....||.
Mosquito  1255 GGSGPGSSTCASSVRSASTAG-LPGSERELLLQADSHGDMEGWMESLRLVC----GSTGQLHSPD 1314

  Fly   112 SDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQIN 176
                                        ||.|:..:                   .|.|  |:|.
Mosquito  1315 ----------------------------YLSGRGGQ-------------------QAEP--QRIA 1330

  Fly   177 QQTKNCYQ------------QSPYMTLNGRKLRALSNE--LGKAAAKESKESPAEEKEQKQEEPP 227
            .||....|            .||.:....::..||.:.  .|::...:|:::|     |.....|
Mosquito  1331 AQTSVQVQGGSVGGSNSGDDYSPVLPAKSQRKYALGSRSPSGQSPVTKSRKTP-----QAGCSSP 1390

  Fly   228 PPAVDP-------MPLVYEKPHHF---------------------------KVHTFKGLNWCEFC 258
            ..:.|.       .|..::.|||:                           |..|:||:...:|
Mosquito  1391 TDSADQSIASTSNQPAYHQPPHHYQQQQQQQHHHHHHHGAKDSSDRESGSPKSKTWKGIMAAKF- 1454

  Fly   259 ANFLWGFTA--------QGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPH 315
            ....|...|        .|:..|.|...:.::.
Mosquito  1455 RKMQWQPAAADLPDNAPTGLPLELCPVSSRNRF-------------------------------- 1487

  Fly   316 HQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTL 380
              :|.||.:|:..||::|:|..||||:.|....|.||...::|..::..:::..:.:|||::..|
Mosquito  1488 --LPLVVEKCISVVESKGLLVVGIYRIPGNTAAIAALTETINRGLDEVALNDPRWDDVNVVSSLL 1550

  Fly   381 KLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMA--EAVRRLPPAHHSCLQYMLEHLKRVAS 443
            |.:.|.||.|::....|..|::|   .:|:.||:|:|  :.:.|:|..::..|:|::.||..|.:
Mosquito  1551 KAFFRNLPQPVLPDAMYRGFISA---DQQSGQRRLIALRQMLERIPRMNYETLKYLMRHLVLVTA 1612

  Fly   444 HYAVNKMNEHNLATVFAPTLI 464
            |...|.|:..|||.||.|:::
Mosquito  1613 HSEANLMDPRNLAIVFGPSVV 1633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	19/99 (19%)
		C1_CHN	241..293	CDD:410356	13/86 (15%)
		RhoGAP_chimaerin	302..491	CDD:239837	50/165 (30%)
RhoGAP19D	XP_061502159.1	None