DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap27l

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_694888.4	Gene:	arhgap27l / 566523	ZFINID:	ZDB-GENE-120406-11	Length:	1014	Species:	Danio rerio

Alignment Length:	510	Identity:	126/510 - (24%)
Similarity:	202/510 - (39%)	Gaps:	121/510 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RCQRTLP---LPPAK-STAEAVE------ANNLAGRLYGSEYHGLMGHLEAEQLLA-NARDGSYF 105
            :||.|||   :||.: .....||      .||.....:......|.......::.: ||.|.| .
Zfish   535 KCQWTLPEASVPPGQPMNGNGVEQDGPPVLNNWRYTQFNISQEDLKFSPSHRRIASDNASDAS-S 598

  Fly   106 VRRSPQSDGYYTLSLRFNKR----------PKHYKLLYKPGV---------GHYLRGQDKRFDTV 151
            ...||:|..|   ..:|.:|          ..|:..|.|.|:         |..||   |.:...
Zfish   599 SGNSPESQHY---DKKFRRRRNLSSYSTDSHSHHSSLEKAGILNKTKVAENGKRLR---KNWAQS 657

  Fly   152 HDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMT--LNGRKLRALSNELGKAAAKESKES 214
            ..::.||::.||.....:|  ..::.:|.   |..|..|  |.|..|...|.|      |.||::
Zfish   658 WTVLHDGVLTFHKDPKFAP--AGMSSKTN---QIVPEYTVELKGATLSWASKE------KSSKKN 711

  Fly   215 PAEEK------------------------------------EQKQEEPPPPAVDPMPLVYE-KPH 242
            ..|.|                                    ..:.|....|...|:|...| ||.
Zfish   712 VLELKTRHGSEYLIQYDTDSIIQDWQKIILDTIKLLHEHGHNSEDEAEDVPEKSPLPADKEKKPE 776

  Fly   243 HFKVHTFKGLNWCEFCANFLWGFTAQG-VKCEACGFVAHSKCSELVPPKCVPDLKRIR------- 299
            ..::.:...::            |.|| |:.:...|:...           |.|:.::
Zfish   777 AARLSSTSSID------------TDQGRVRTKLRKFLQRR-----------PTLQSVKEKGYIKE 818

  Fly   300 GVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTD 364
            .|||..|.|:...| :..:|..|.:|:..||.||:..:|||||||....|:.|:...|.| |..|
Zfish   819 NVFGCHLDTLCHRE-NTTVPKFVEKCIRSVEKRGLKIDGIYRVSGNLAVIQKLRYKADHE-EDLD 881

  Fly   365 MSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHS 429
            :.:..:..::||.|.|||:||.||.||..|..:..|:||.:....:::...:.:.||.||..:|.
Zfish   882 LEDGQWEEIHVITGALKLFLRELPEPLFPFSFFDKFIAAIQISDYSQKVSYIRDLVRNLPLPNHD 946

  Fly   430 CLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLI 484
            .::.:..||::|..|..:|:|:..:.|.||.|||: .||..:|:|..:...:.::
Zfish   947 TMEVLFRHLRKVIEHGEMNRMSVQSTAIVFGPTLL-RPQEESNITMHMVFQNQIV 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	23/110 (21%)
		C1_1	242..294	CDD:278556	5/52 (10%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/183 (34%)
arhgap27l	XP_694888.4	SH3_ARHGAP27	15..71	CDD:213002
		WW	340..368	CDD:278809
		WW	394..422	CDD:278809
		PH	632..745	CDD:278594	26/126 (21%)
		PH_ARHGAP9-like	633..744	CDD:270053	25/124 (20%)
		RhoGAP_ARHGAP27_15_12_9	821..1006	CDD:239868	62/183 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920