DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and gmip

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_694162.5	Gene:	gmip / 565801	ZFINID:	ZDB-GENE-130530-823	Length:	1017	Species:	Danio rerio

Alignment Length:	485	Identity:	117/485 - (24%)
Similarity:	203/485 - (41%)	Gaps:	108/485 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMG----------HLEAEQLLANARDGSYFVRR 108
            |:|.|:|.|....:...|....|..|   .|.::|          ::..|.:..|        ||
Zfish   338 QQTEPVPLAYQNLQLTCAPCEPGEPY---LHYILGKRLPDQPPQIYIFQEFIPQN--------RR 391

  Fly   109 SPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVA--DGLINFHMQLHASPI 171
            ||.:                              |:.|:.:...|:.|  |.|      .|:|.:
Zfish   392 SPPT------------------------------GRRKQSNIQQDLYALPDDL------KHSSSL 420

  Fly   172 IQ-----QINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEP----- 226
            :.     |.::.:....:.........|||...|: .|..::.:..|...||.|:...:.
Zfish   421 VDGRRPGQSDRDSTGSLESLSSPAHGTRKLPKASS-TGTMSSDDLDEKDPEESEEGLSDSNGMTC 484

  Fly   227 PPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKC 291
            .|.:.....|.    |..:....|.:. |:.|.|::   ...|::||.||...|.||.|:    |
Zfish   485 KPRSASRAALT----HRLRKMKSKMVK-CKQCDNYI---LVNGIECEECGLAVHRKCLEV----C 537

  Fly   292 VPDLKRIRG-VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLA 355
            ..:.:..|| ||||:.:::.: |....:||||.||.||:|.|.:..:|:||:||....:..|..|
Zfish   538 QLECEHRRGFVFGTEFSSLPR-ETQDSVPFVVLRCTEEIENRALGVQGVYRISGSKPRVLKLCQA 601

  Fly   356 LDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEA- 419
            .:.:.::.|:|:.   :.:.|...||.:.:.||.||:||..|..|:|.|:..::..::...||:
Zfish   602 FEIQKDQVDLSDL---SPHDITSVLKHFFKELPEPLLTFDLYNDFIAVGKEIQRLSEKDHAAESP 663

  Fly   420 -------------VRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPT----LIATP 467
                         :.|||..::..:|:|:.||.|||..:..|||:..||..||.||    |::..
Zfish   664 GIVENIVRRLRELIGRLPVCNNITVQHMMAHLNRVAEQFEDNKMSPGNLGIVFGPTLLRPLVSGD 728

  Fly   468 QHMTNLTE---EIFMLSSLITHCKTIFATS 494
            ..|..|.|   :..::..:|::...:|.::
Zfish   729 VSMIALLETSYQALLVEFMISNYDQVFGSA 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	16/102 (16%)
		C1_1	242..294	CDD:278556	15/51 (29%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/209 (30%)
gmip	XP_694162.5	BAR	129..337	CDD:299863
		C1	499..541	CDD:197519	14/49 (29%)
		RhoGAP	549..750	CDD:295372	62/204 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820