Protein Alignment RhoGAP5A and gmip

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_694162.5
• Gene: gmip / 565801
• ZFINID: ZDB-GENE-130530-823
• Length: 1017
• Species: Danio rerio
• Alignment Length: 485
• Identity: 117/485 - (24%)
• Similarity: 203/485 - (41%)
• Gaps: 108/485 - (22%)

  Fly    54 QRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMG----------HLEAEQLLANARDGSYFVRR 108
            |:|.|:|.|....:...|....|..|   .|.::|          ::..|.:..|        ||
Zfish   338 QQTEPVPLAYQNLQLTCAPCEPGEPY---LHYILGKRLPDQPPQIYIFQEFIPQN--------RR 391

  Fly   109 SPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVA--DGLINFHMQLHASPI 171
            ||.:                              |:.|:.:...|:.|  |.|      .|:|.:
Zfish   392 SPPT------------------------------GRRKQSNIQQDLYALPDDL------KHSSSL 420

  Fly   172 IQ-----QINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEP----- 226
            :.     |.::.:....:.........|||...|: .|..::.:..|...||.|:...:.
Zfish   421 VDGRRPGQSDRDSTGSLESLSSPAHGTRKLPKASS-TGTMSSDDLDEKDPEESEEGLSDSNGMTC 484

  Fly   227 PPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKC 291
            .|.:.....|.    |..:....|.:. |:.|.|::   ...|::||.||...|.||.|:    |
Zfish   485 KPRSASRAALT----HRLRKMKSKMVK-CKQCDNYI---LVNGIECEECGLAVHRKCLEV----C 537

  Fly   292 VPDLKRIRG-VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLA 355
            ..:.:..|| ||||:.:::.: |....:||||.||.||:|.|.:..:|:||:||....:..|..|
Zfish   538 QLECEHRRGFVFGTEFSSLPR-ETQDSVPFVVLRCTEEIENRALGVQGVYRISGSKPRVLKLCQA 601

  Fly   356 LDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEA- 419
            .:.:.::.|:|:.   :.:.|...||.:.:.||.||:||..|..|:|.|:..::..::...||:
Zfish   602 FEIQKDQVDLSDL---SPHDITSVLKHFFKELPEPLLTFDLYNDFIAVGKEIQRLSEKDHAAESP 663

  Fly   420 -------------VRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPT----LIATP 467
                         :.|||..::..:|:|:.||.|||..:..|||:..||..||.||    |::..
Zfish   664 GIVENIVRRLRELIGRLPVCNNITVQHMMAHLNRVAEQFEDNKMSPGNLGIVFGPTLLRPLVSGD 728

  Fly   468 QHMTNLTE---EIFMLSSLITHCKTIFATS 494
            ..|..|.|   :..::..:|::...:|.::
Zfish   729 VSMIALLETSYQALLVEFMISNYDQVFGSA 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	16/102 (16%)
		C1_CHN	241..293	CDD:410356	15/51 (29%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/209 (30%)
gmip	XP_694162.5	BAR	129..337	CDD:472257
		C1_GMIP-like	494..545	CDD:410366	16/62 (26%)
		RhoGAP	549..750	CDD:470621	62/204 (30%)