DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and abr

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001355623.1	Gene:	abr / 565190	ZFINID:	ZDB-GENE-070705-146	Length:	1061	Species:	Danio rerio

Alignment Length:	477	Identity:	130/477 - (27%)
Similarity:	191/477 - (40%)	Gaps:	124/477 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WKPELYKLQLEAPAPCPL----------RC--QRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGL 86
            |:..:.|||.:....|.|          .|  .||:...|..|..:..|:..|.|.|: ...|..
Zfish   651 WRESIQKLQKKDLQACVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDEESPGLYGFLH-VIVHKA 714

  Fly    87 MGHLEAEQLLANARDGS--YFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFD 149
            .|..|:..|.......|  |||.::.      |...|....|:..:
Zfish   715 TGFKESANLYCTLEVDSFGYFVSKAK------TRVFRDTTEPQWNE------------------- 754

  Fly   150 TVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNE-----LGKAAAK 209
                       .|.::|..|..::.:..:  .||.:|        ||....||     :||...:
Zfish   755 -----------EFEIELEGSQCLRILCYE--KCYDKS--------KLNKDDNEIVDKIMGKGQVQ 798

  Fly   210 ESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEA 274
                                 :||. .|..|..|..|....|:.     ..|...||::.:..
Zfish   799 ---------------------LDPQ-TVQSKNWHMDVIEMNGIK-----VEFSMKFTSRDLSL-- 834

  Fly   275 CGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGI 339
                           |..|. |:..||||..::.:.:.| ..::|::||:|:||||.||:.:.||
Zfish   835 ---------------KRTPS-KKQSGVFGVKISVVTKRE-RSKVPYIVRQCIEEVEKRGIDEVGI 882

  Fly   340 YRVSGFADEIEALKLALDREGEK-----TDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPS 399
            ||:||.|.:|:|||.|.|...:.     :||      ::|.||||||||.|.||.||:|.:.||:
Zfish   883 YRISGVATDIQALKAAFDANTKDILMMLSDM------DINAIAGTLKLYFRELPEPLLTDRLYPA 941

  Fly   400 FMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI 464
            ||........|.:...|...:|.||..:......:||||||||....:|||:.|||||||.|||:
Zfish   942 FMEGISLSDPAAKENCMMHLLRSLPDPNLITFLTLLEHLKRVAEKEPINKMSLHNLATVFGPTLL 1006

  Fly   465 ATPQHMTNLTEEIFMLSSLITH 486
             .|....:...:|.:.|.:.:|
Zfish  1007 -RPSESESSKAQITLASDIWSH 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	14/92 (15%)
		C1_1	242..294	CDD:278556	7/51 (14%)
		RhoGAP_chimaerin	302..491	CDD:239837	77/190 (41%)
abr	NP_001355623.1	Bcr-Abl_Oligo	3..74	CDD:312543
		RhoGEF	295..483	CDD:214619
		PH-like	477..661	CDD:354315	4/9 (44%)
		C2_ABR	707..827	CDD:176068	32/193 (17%)
		RhoGAP_Bcr	846..1042	CDD:239852	77/190 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940