Protein Alignment RhoGAP5A and arhgap29a

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_693227.4
• Gene: arhgap29a / 564805
• ZFINID: ZDB-GENE-030131-9510
• Length: 1344
• Species: Danio rerio
• Alignment Length: 624
• Identity: 138/624 - (22%)
• Similarity: 232/624 - (37%)
• Gaps: 175/624 - (28%)

  Fly    30 VQKVWKPELYKLQLEAPAPCP----LRCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHL 90
            |::.|:.|..|:. ||.:...    |:.||......|:|:...||...::|.  |.:.......|
Zfish   344 VKEQWQREQKKMH-EADSALRKARLLQAQRQEEYEKARSSTSRVEEEQISGA--GGKQLEKRRKL 405

  Fly    91 EAEQLLANARDGSYF--------VRR---------------------------------SPQSDG 114
            |.|.||.......::        |:|                                 ..|...
Zfish   406 EEEALLKAEEAQDHYKLCVTDVGVKRVDLAKTKSEILTQIRELVFQCDLTLKAVTVNWFQMQQAQ 470

  Fly   115 YYTLSLRFNKRPKHYKLLYKPGV----------GHYLRGQDKRFD-------------------T 150
            ..:|.:.|....::.| ||:||:          ....|.:...||                   .
Zfish   471 VASLPINFQSLCENSK-LYEPGLCYTEFVKSLPSDRSRVESFSFDISSTHNTGLKRAVNSTPAAL 534

  Fly   151 VH------DMVADGLINFHMQLHASPIIQQINQQTKNCYQ---QSPY----MTLNGRKLRALSNE 202
            ||      |.::...:..|:|...:.:....:..|.:...   |.|:    .:..|..:.:.|..
Zfish   535 VHLSQVSGDFLSADEVESHVQARTAKMPDGRSHSTTDVQALRIQGPFRVWRTSSQGGGMCSDSES 599

  Fly   203 LGKAAAKESKESP----------------------AEEKEQKQEEPPPP------------AVDP 233
            .|.::...|.:||                      |::.:::  |||.|            |..|
Zfish   600 AGGSSESRSMDSPTASPGDFKRRLPRTPSTGTMSSADDLDER--EPPSPSDNGLSEMVTEAASSP 662

  Fly   234 MPL----VYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPD 294
            .|.    :.:.....|:...:..:.|..|.:.:   ...|.:||.|....|.||.|.:..:|  .
Zfish   663 GPFRNTQMSKAAQTHKLRKLRAPSKCRECDSLV---VFHGAECEECSLACHKKCLETLAIQC--G 722

  Fly   295 LKRIRG---VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLAL 356
            .|:::|   :|..|.....:..| ..|||::::|..|:|.|.:..:|||||:|....:|.|..|.
Zfish   723 HKKLQGKLHLFAIDFAQAAKNSP-DGIPFIIKKCTSEIENRALNIKGIYRVNGAKSRVEKLCQAF 786

  Fly   357 DREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMA--------------AGRTG 407
            :...:..::|:.   ..:.|:..||||||.||.|||.|:.|..|:.              |.|..
Zfish   787 ENGKDLVELSDL---YPHDISNVLKLYLRQLPEPLILFRYYNDFIGLAKESQSIIVDEVEASRGC 848

  Fly   408 KQAEQRQLMAE----------AVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPT 462
            ..::..|:..|          .:|:|||||:..||::::||.||:.....|||...||..:|.||
Zfish   849 PTSDTPQISVELNRVLFKIKDLLRQLPPAHYKTLQFLIQHLHRVSERADENKMTSSNLGIIFGPT 913

  Fly   463 LIATPQ-----HMTNLTE---EIFMLSSLITHCKTIFAT 493
            ||...|     .:::|.:   :..::..||.|.:.||.|
Zfish   914 LIKPRQADAEVSLSSLVDYPYQALIVELLIRHYEMIFDT 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	24/166 (14%)
		C1_1	242..294	CDD:278556	12/51 (24%)
		RhoGAP_chimaerin	302..491	CDD:239837	66/220 (30%)
arhgap29a	XP_693227.4	BAR	230..484	CDD:299863	25/142 (18%)
		C1	675..721	CDD:197519	11/48 (23%)
		RhoGAP	733..945	CDD:295372	65/215 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850