DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP5A and arhgap27

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_005156083.1	Gene:	arhgap27 / 564211	ZFINID:	ZDB-GENE-030131-3922	Length:	999	Species:	Danio rerio

Alignment Length:	349	Identity:	91/349 - (26%)
Similarity:	143/349 - (40%)	Gaps:	80/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 DTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKE 213
            ||:|.:..|               |..:::......:||  ||: |:.|.........|.::...
Zfish   723 DTIHQLNGD---------------QHHSEEEDEVIDKSP--TLD-REERPFEKRTMSTATRQPST 769

  Fly   214 SPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFV 278
            |...|.|||                      ||.|       :.....|...|.|.||.:  |::
Zfish   770 SSTSEAEQK----------------------KVRT-------KLKKFLLKRPTLQSVKDK--GYI 803

  Fly   279 AHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVS 343
            ..:                   |||..|..:...| ..::|..|.:|:..||.||:..:|:||||
Zfish   804 REN-------------------VFGCHLHNLCSQE-KTRVPSFVEKCIRAVEKRGLEIDGLYRVS 848

  Fly   344 GFADEIEALKLALDREGEKTDMSETAYGN--VNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRT 406
            |....|:.|:...|.  |..|:.|   ||  ::||.|.|||:.|.|..||..:..:..|:.|.:|
Zfish   849 GNLAVIQKLRFKADH--EDLDLEE---GNWDIHVITGALKLFFRELQEPLFPYNLFNEFICAIKT 908

  Fly   407 GKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMT 471
            .....:...|...||.|||.:|..::.:..||:||..|...|:|...|:|.||.|||:...:...
Zfish   909 PDYYSKISHMRNLVRSLPPPNHDTMEALFSHLRRVIQHGNENRMTVQNVAIVFGPTLLKPEEETA 973

  Fly   472 NL-TEEIF---MLSSLITHCKTIF 491
            :: |..:|   ::..|::..::||
Zfish   974 SIATYMVFQNQIVEFLLSEFESIF 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	4/16 (25%)
		C1_1	242..294	CDD:278556	9/51 (18%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/194 (32%)
arhgap27	XP_005156083.1	SH3	22..77	CDD:302595
		WW	315..343	CDD:278809
		WW	382..410	CDD:278809
		PH	613..726	CDD:278594	2/2 (100%)
		PH_ARHGAP9-like	614..725	CDD:270053	1/1 (100%)
		RhoGAP_ARHGAP27_15_12_9	808..992	CDD:239868	62/189 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920