DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and myo9ab

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021326243.1	Gene:	myo9ab / 562199	ZFINID:	ZDB-GENE-080424-6	Length:	2343	Species:	Danio rerio

Alignment Length:	381	Identity:	100/381 - (26%)
Similarity:	169/381 - (44%)	Gaps:	50/381 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVA--DGLI 160
            :|.||        |.|  ..:.:.|.|..|.::|.........|...|.|.....|:.|  :.::
Zfish  1673 DAEDG--------QKD--TAVDVVFKKALKEFRLNIFNSYSTALAMDDGRSIRYKDLYALFEHIL 1727

  Fly   161 NFHMQLH-----ASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKE 220
            ...|:|.     .||:...:|  |...:... :||    :.:.:...:.||...|.|:...:|.:
Zfish  1728 EKSMRLEQRDWSESPVKVWVN--TFKVFLDE-FMT----EYKPMDGTISKAPKPERKKRRKKESD 1785

  Fly   221 QKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSE 285
            ..:|              ...|.||...:....:||||::.:| ...:...|:.|.:..|.||..
Zfish  1786 TVEE--------------HMGHIFKSTQYSIPTYCEFCSSLIW-MMDKACVCKLCRYACHKKCCL 1835

  Fly   286 LVPPKCV----PDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFA 346
            .:..||.    |:|...:  ||.:|:.:...|  ..:|.||.:.:..:|..|:..|||||.||..
Zfish  1836 RMTTKCSKKFDPELSSRQ--FGVELSRLTSDE--RSVPLVVEKLINYIEMHGLYTEGIYRKSGST 1896

  Fly   347 DEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAE 411
            ::|:.||..||.:....::.:.   |::|||..||.:||.||.||:||:.|..|:.|.....:.|
Zfish  1897 NKIKELKQGLDTDANSVNLDDY---NIHVIASVLKQWLRDLPNPLMTFELYEEFLRAMGLQDKRE 1958

  Fly   412 QRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATP 467
            ..|.:...:.:|...|.:.|:.::.||.|::.....|:|:.:.||.||||.::..|
Zfish  1959 VVQGVYSIIDQLSRTHLNTLERLIFHLVRISFQEETNRMSANALAIVFAPCILRCP 2014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	15/69 (22%)
		C1_1	242..294	CDD:278556	15/55 (27%)
		RhoGAP_chimaerin	302..491	CDD:239837	55/166 (33%)
myo9ab	XP_021326243.1	UBQ	7..111	CDD:320785
		MYSc_Myo9	163..991	CDD:276836
		C1	1793..1841	CDD:237996	13/48 (27%)
		RhoGAP_myosin_IXA	1854..2039	CDD:239871	55/166 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810