DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap45a

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_001919378.4	Gene:	arhgap45a / 556955	ZFINID:	ZDB-GENE-140106-47	Length:	1106	Species:	Danio rerio

Alignment Length:	391	Identity:	100/391 - (25%)
Similarity:	171/391 - (43%)	Gaps:	81/391 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 IIQQINQQTKNCYQ--QSPYMTLN-------GRKLRALSNELGK--------AAAKESKESPAEE 218
            :::|...|.::.:|  :|...||:       |..|.:.:|..|.        :||..|.....||
Zfish   614 VVKQRRGQVRDHHQAHKSWPSTLSDTDSVGPGSGLGSPTNSTGDISKPSRPVSAATLSSNEDLEE 678

  Fly   219 KE--QKQEEPPPPAVDPMPLVYEKPHH-------FKVHTFKGL---NWCEFCANFLWGFTAQGVK 271
            ::  ..|.|.....::|..:....|..       .|.|..:.|   :.|..|.::::   .||.:
Zfish   679 RDGAMTQFEQSINGIEPEIVAPTGPFRNVGLSKAAKTHRLRKLRTPSKCRECDSYVY---FQGAE 740

  Fly   272 CEACGFVAHSKCSELVPPKCVPDLKRIRG---VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARG 333
            ||.|....|.||.|.:..:|  ..|:::|   :||.|.:.::. .....:||::::|:.|:|.|.
Zfish   741 CEECFLACHKKCLESLAIQC--GHKKLQGRLQLFGRDFSQVLH-GKEDAVPFIIKKCITEIERRA 802

  Fly   334 MLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYP 398
            :..:|||||:|....:|.|..|.:...|..::|:   .:.:.|:..||||||.||.|::.|:.|.
Zfish   803 LKMKGIYRVNGVKTRVEKLCQAFENGKELVELSQ---ASPHDISNVLKLYLRQLPEPIMPFRMYN 864

  Fly   399 SFMAAGR---------------------TGKQAEQRQL-----MAEAVRRLPPAHHSCLQYMLEH 437
            ..|...:                     .|.:.|...|     :.|.::|||.|:.:.|:|:::|
Zfish   865 ELMGLAKESLNSDASESTDGVKSPELVDRGPETEAEVLTLVDKLREVLKRLPNANIATLKYIIQH 929

  Fly   438 LKRVASHYAVNKMNEHNLATVFAPTLI------ATPQ--------HMTNLTEEIFMLSSLITHCK 488
            |:||:.....|||:..||..||.|||:      ||..        |...:.|.:.:....|..|.
Zfish   930 LRRVSELEQENKMSASNLGIVFGPTLMRPKPTGATVSLSSLVDYPHQARIVEALIVFQQSIFICT 994

  Fly   489 T 489
            |
Zfish   995 T 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	15/61 (25%)
		RhoGAP_chimaerin	302..491	CDD:239837	64/228 (28%)
arhgap45a	XP_001919378.4	BAR	293..541	CDD:299863
		C1	715..760	CDD:197519	13/47 (28%)
		RhoGAP	772..986	CDD:295372	61/217 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920