Protein Alignment RhoGAP5A and MYO9B

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_004136.2
• Gene: MYO9B / 4650
• HGNCID: 7609
• Length: 2157
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 100/356 - (28%)
• Similarity: 157/356 - (44%)
• Gaps: 56/356 - (15%)

  Fly   151 VHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKES---- 211
            :|....|.:.|:  |:..|.:..:..|:..|       :.||  ..::|.:|..:...|..
Human  1558 IHVGYKDLMENY--QIVVSNLATERGQKDTN-------LVLN--LFQSLLDEFTRGYTKNDFEPV 1611

  Fly   212 KESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACG 276
            |:|.|::|::|||.    ||..     ...|.|..:.......||.|.:::| ...:.:.|..|.
Human  1612 KQSKAQKKKRKQER----AVQE-----HNGHVFASYQVSIPQSCEQCLSYIW-LMDKALLCSVCK 1666

  Fly   277 FVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHH-------------QIPFVVRRCVEE 328
            ...|.||...:...|.....| :|..|        :||.|             .:|.|:.:.:|.
Human  1667 MTCHKKCVHKIQSHCSYTYGR-KGEPG--------VEPGHFGVCVDSLTSDKASVPIVLEKLLEH 1722

  Fly   329 VEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGN--VNVIAGTLKLYLRLLPVPL 391
            ||..|:..||:||.||.|:....|:.||     :||.:.....|  ::.|.|.||.:||.||.||
Human  1723 VEMHGLYTEGLYRKSGAANRTRELRQAL-----QTDPAAVKLENFPIHAITGVLKQWLRELPEPL 1782

  Fly   392 ITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLA 456
            :||..|..|:.|....::.||...:...:..||.|:|:.|:.::.||.:||....||:|:...||
Human  1783 MTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALA 1847

  Fly   457 TVFAPTLIATPQHMTNLTEEIFMLSSLITHC 487
            .:|||.|:..|.:...||....:|.  ||.|
Human  1848 IIFAPCLLRCPDNSDPLTSMKDVLK--ITTC 1876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	3/14 (21%)
		C1_CHN	241..293	CDD:410356	12/51 (24%)
		RhoGAP_chimaerin	302..491	CDD:239837	65/201 (32%)
MYO9B	NP_004136.2	RA_Myosin-IXb	16..112	CDD:340737
		MYSc_Myo9	160..941	CDD:276836
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..734
		Actin-binding. /evidence=ECO:0000305	844..855
		Neck or regulatory domain. /evidence=ECO:0000305	940..1044
		IQCD	972..>1001	CDD:467745
		IQ	1000..1022	CDD:197470
		Tail. /evidence=ECO:0000305	1045..2157		100/356 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1298
		PTZ00121	<1050..1630	CDD:173412	21/91 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1320..1410
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1455..1484
		C1_Myosin-IXb	1628..1685	CDD:410434	12/62 (19%)
		RhoGAP_myosin_IXB	1698..1883	CDD:239872	61/186 (33%)
		Interaction with RHOA. /evidence=ECO:0000269|PubMed:26529257	1739..1744		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2157
		PHA03307	<1985..>2140	CDD:223039