Protein Alignment RhoGAP5A and MYO9A

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 116/489 - (23%)
• Similarity: 203/489 - (41%)
• Gaps: 114/489 - (23%)

  Fly    23 APEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTL-----PLPPAKSTAEAVEANNLAGRLYGSE 82
            |..|:.|:    .|||           |..|::..     |.|.|| ...:|:.:|:|
Human  1875 AYHPTPPL----SPEL-----------PGSCRKEFKENKEPSPKAK-RKRSVKISNVA------- 1916

  Fly    83 YHGLMGHLEAEQLLANARD----GSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRG 143
            ...:....::.|::|:..|    ..:.:::....|                             .
Human  1917 LDSMHWQNDSVQIIASVSDLKSMDEFLLKKVNDLD-----------------------------N 1952

  Fly   144 QDKRFDTVHDMV----------------------ADGLINFHMQLHASPIIQQINQQTKNCYQ-- 184
            :|.:.||:.|:|                      .||....:..|:|  :.:||.::|....|
Human  1953 EDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYA--LFEQILEKTMRLEQRD 2015

  Fly   185 ---QSPY-MTLNGRK--LRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYE-KPH 242
               :||. :.:|..|  |....||...:....:|....|.|:::::|        ..||.| ..|
Human  2016 SLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPKTERKKRRKKE--------TDLVEEHNGH 2072

  Fly   243 HFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCV----PDLKRIRGVFG 303
            .||...:....:||:|::.:|......| |:.|.:..|.||......||.    |:|...:  ||
Human  2073 IFKATQYSIPTYCEYCSSLIWIMDRASV-CKLCKYACHKKCCLKTTAKCSKKYDPELSSRQ--FG 2134

  Fly   304 TDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSET 368
            .:|:.:...:  ..:|.||.:.:..:|..|:..|||||.||..::|:.|:..||.:.|..::.:.
Human  2135 VELSRLTSED--RTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDY 2197

  Fly   369 AYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQY 433
               |::|||...|.:||.||.||:||:.|..|:.|....::.|..:.:...:.:|...|.:.|:.
Human  2198 ---NIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLER 2259

  Fly   434 MLEHLKRVASHYAVNKMNEHNLATVFAPTLIATP 467
            ::.||.|:|.....|:|:.:.||.||||.::..|
Human  2260 LIFHLVRIALQEDTNRMSANALAIVFAPCILRCP 2293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	12/116 (10%)
		C1_CHN	241..293	CDD:410356	15/55 (27%)
		RhoGAP_chimaerin	302..491	CDD:239837	53/166 (32%)
MYO9A	XP_011519915.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1004	CDD:276836
		C1_Myosin-IXa	2067..2124	CDD:410433	16/57 (28%)
		RhoGAP_myosin_IX	2133..2318	CDD:239842	53/166 (32%)