DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and gmip

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_031753686.1	Gene:	gmip / 448355	XenbaseID:	XB-GENE-977540	Length:	950	Species:	Xenopus tropicalis

Alignment Length:	546	Identity:	126/546 - (23%)
Similarity:	193/546 - (35%)	Gaps:	167/546 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LRCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSD-- 113
            |..||...|..||..:..:|...:|.           ||..:...|...|..|   |...||.
Frog   288 LYIQRCDDLEKAKLLSAKIEEEQIAS-----------GHTGSANKLVEKRRKS---REEAQSKAI 338

  Fly   114 ----GYYTLSLRFNKRPKHYKLLYKPGVGH------------------YLRGQDKRFDTVHDMVA 156
                .|.:.....|.|.:..:.:.:..|.|                  .||.:..:|:.:.....
Frog   339 EAEASYRSCVQEANARSQQQEKVRERIVSHIRKLIIQGDQVLKEVTMNLLRMKQSQFEAIPCGYG 403

  Fly   157 DGL------------INFHMQL---HASPIIQQINQQTKNCYQQSPYMTLNGRKLRA-----LSN 201
            |.|            :.|.:.|   |..|......:....| |:||.:   ||:..|     :|:
Frog   404 DLLTTCDPYESGTRYLQFILTLPRKHTDPEKFTFEEYIPAC-QRSPSV---GRRKNAVQLVRVSS 464

  Fly   202 ELGKAAAK----------------------ESKESPAEEKEQKQEEPP-----------PPA--- 230
            .|.:..||                      ...||.....|.:.:|.|           |.|
Frog   465 SLSELYAKTEDGILKISAGERGSWGSKIPSSDSESMGGTSESRSQESPSDSPGDFVRRVPKASST 529

  Fly   231 ------------------VDPMPLVYEK--PHH-----------FKVHTFKGL---NWCEFCANF 261
                              ||......|.  |.|           .:.|.||..   ..|..|.||
Frog   530 GTMSSDDLDERDSFNAEDVDSTDATSENGLPLHSMDRLGVLSLAAQSHRFKRTRVPTKCRECENF 594

  Fly   262 LWGFTAQGVKCEACGFVAHSKCSELVPPKC--------VPDLKRIRGVFGTDLTTMVQLEPHHQI 318
            :    ..||:||.|....|.||.|.:..:|        ||       :||.|.:...:..| .::
Frog   595 M----VSGVECEECFLTCHRKCLENLLIRCGHRKLPSKVP-------LFGVDFSQFPRYFP-EEV 647

  Fly   319 PFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLY 383
            ||::.||..|:|.|.:.|:|:||:||....:|.|..|.:...:..|:|.   .:.:.|...||.:
Frog   648 PFIIVRCTAEIEQRALGQQGLYRISGAKARVEKLLQAFENGRDLVDLSG---HSPHDITSALKHF 709

  Fly   384 LRLLPVPLITFQAYPSFMAAGR----------TGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHL 438
            |:.||..::.:..|..|||..|          ||..|..:  |.:.:..:|.::::.|:::..||
Frog   710 LKQLPDSVVPYHLYEQFMAFSREFLEDTKENETGNDAIHQ--MKDLLCSMPHSNYNTLRHLTAHL 772

  Fly   439 KRVASHYAVNKMNEHNLATVFAPTLI 464
            .||:..:..||||.:||..:|.||||
Frog   773 YRVSERFEDNKMNPNNLGIIFGPTLI 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	20/126 (16%)
		C1_1	242..294	CDD:278556	19/73 (26%)
		RhoGAP_chimaerin	302..491	CDD:239837	54/173 (31%)
gmip	XP_031753686.1	BAR	156..380	CDD:416402	21/105 (20%)
		C1_GMIP-like	575..624	CDD:410366	17/52 (33%)
		RhoGAP_GMIP	632..827	CDD:239873	54/173 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010