DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and chn1

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_998165.1	Gene:	chn1 / 406273	ZFINID:	ZDB-GENE-040426-1934	Length:	459	Species:	Danio rerio

Alignment Length:	463	Identity:	190/463 - (41%)
Similarity:	273/463 - (58%)	Gaps:	57/463 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLA 97
            |||..||:||.|||.|..:.|...:...|               :.||.|||||:...:.:.||:
Zfish    15 VWKSYLYQLQQEAPHPRRVTCTSEVENRP---------------KYYGREYHGLISREDGDLLLS 64

  Fly    98 NARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINF 162
            .| :|||.:|.|.:..|.|||:|||..:.::::|.|.   |.:..| :|||:::||:|.||||..
Zfish    65 VA-EGSYLIRESQRQPGTYTLALRFGNQTRNFRLFYD---GKHFVG-EKRFESIHDLVTDGLITL 124

  Fly   163 HMQLHASPIIQQINQQTKN-CYQQSPYMTLNG----RKLRALSNELGKAAAKESKESPAEE---K 219
            :::..|:   :.|::.|.| .|:...|.|||.    :|...:..:|     .:.|.||||:   :
Zfish   125 YIETKAA---EYISKMTINPIYEHVGYTTLNREPALKKTLPVCKDL-----PDGKHSPAEDSGLE 181

  Fly   220 EQ----------KQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEA 274
            |:          |:.|..|.        |||.|:||||||:|.:|||:||||:||..||||||..
Zfish   182 ERLTSLVRRATLKESERVPK--------YEKVHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCAD 238

  Fly   275 CGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGI 339
            ||...|.:||::||..|.||||.::.|:..||||:|:.. :.:.|.||..|:.|:||||:..||:
Zfish   239 CGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAH-NAKRPMVVDMCIREIEARGLQSEGL 302

  Fly   340 YRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAG 404
            ||:|||:|.||.:||:.||:|||.|:|...|.::|||:|.||||.|.||:|:||:.|||.|:.|.
Zfish   303 YRISGFSDLIEDVKLSFDRDGEKADISVNVYEDINVISGALKLYFRDLPIPVITYDAYPRFIQAA 367

  Fly   405 RTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATP-- 467
            :.....|:.:.:.||::.|||||...|:|::.|||||..:...|.||..||..||.|||:..|
Zfish   368 KLTDPDERLEALHEALKLLPPAHCETLRYLMAHLKRVTQNEKDNLMNAENLGIVFGPTLMRAPDL 432

  Fly   468 QHMTNLTE 475
            ..||.|.:
Zfish   433 DAMTALND 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	36/90 (40%)
		C1_1	242..294	CDD:278556	31/51 (61%)
		RhoGAP_chimaerin	302..491	CDD:239837	82/176 (47%)
chn1	NP_998165.1	SH2_a2chimerin_b2chimerin	42..128	CDD:198215	37/105 (35%)
		C1_1	206..258	CDD:278556	31/51 (61%)
		RhoGAP_chimaerin	266..459	CDD:239837	82/176 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576386
Domainoid	1	1.000	157	1.000	Domainoid score	I4120
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31056
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2374
OMA	1	1.010	-	-		QHG49440
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	1	1.000	-	-		otm25994
orthoMCL	1	0.900	-	-		OOG6_104322
Panther	1	1.100	-	-	O	PTHR46075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2268
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910