DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap12b

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021335715.1	Gene:	arhgap12b / 393848	ZFINID:	ZDB-GENE-040426-1727	Length:	882	Species:	Danio rerio

Alignment Length:	314	Identity:	82/314 - (26%)
Similarity:	139/314 - (44%)	Gaps:	72/314 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 RALSN-------ELGKAAAKESKESPAEEKEQKQEEPPPPAVD------PMPLVYEKPHHFKVHT 248
            ||||.       |..:|..::..|||..||..|:::|.....:      .|....:|....|:..
Zfish   603 RALSETINTHAWESDEAIEEDMPESPGSEKHDKEKDPRDSKKNRVVKNSSMESSEQKKTRVKLKK 667

  Fly   249 FKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRG-------VFGTDL 306
            |               .|.:                        |.|:.:|.       |||..|
Zfish   668 F---------------LTRR------------------------PTLQAVRDKGYIKDQVFGCSL 693

  Fly   307 TTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYG 371
            |.:.|.| ...:|..|:.|:|.||..|:..:|:|||||....|:.|:.|::.: ||.::.::.:.
Zfish   694 TALCQRE-GTSVPNFVKMCIEHVENTGLNVDGLYRVSGNLAVIQKLRFAVNHD-EKVNLDDSKWE 756

  Fly   372 NVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLE 436
            :::|..|.||:..|.||.||.|:.::..|:.|.:.....::.|.:.:.:::||..:...::.:.:
Zfish   757 DIHVTTGALKMLFRELPEPLFTYASFNDFVEAIKNSDYKQRVQSIKDLIKQLPKPNQETMKVLFK 821

  Fly   437 HLKRVASHYAVNKMNEHNLATVFAPTLIATPQ--------HMT--NLTEEIFML 480
            |||||..|..||:|...::|.||.|||: .|:        ||.  |...|:.:|
Zfish   822 HLKRVIDHGEVNRMTTQSVAIVFGPTLL-RPEIETGNMAVHMVYQNQIVELILL 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	3/51 (6%)
		RhoGAP_chimaerin	302..491	CDD:239837	60/189 (32%)
arhgap12b	XP_021335715.1	SH3_ARHGAP12	17..76	CDD:213003
		SH3-WW_linker	73..267	CDD:318759
		WW	271..297	CDD:306827
		WW	364..389	CDD:306827
		PH_ARHGAP9-like	459..611	CDD:270053	4/7 (57%)
		RhoGAP_ARHGAP27_15_12_9	689..875	CDD:239868	60/189 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920